Predicting outcome in malaria: Correlation between rate of exposure to infected mosquitoes and level of Plasmodium falciparum parasitemia

P. D. McElroy, John C Beier, C. N. Oster, C. Beadle, J. A. Sherwood, A. J. Oloo, S. L. Hoffman

Research output: Contribution to journalArticle

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Abstract

The level of Plasmodium falciparum parasitemia at clinical presentation has repeatedly been shown to correlate with severity of disease. Using data collected in western Kenya over 21 months, we examined associations between exposure variables, especially exposure to infective mosquitoes, and prevalence and density of P. falciparum parasitemia among 1,007 children six months to six years of age. The prevalence of P. falciparum infection was similar at all exposure levels, but there was a correlation between exposure to sporozoite-infected mosquitoes over the previous 28-day period, and geometric mean parasite density of each cohort (Spearman rank coefficient = 0.724, P = 0.002). The relative odds of having a parasite density ≥ 5,000/μl was increased almost two-fold among individuals exposed to more than 10 infective bites during the prior 28-day period. Children enrolled during the highest incidence period were 80% more likely to have a density ≥ 5,000/μl relative to individuals enrolled during periods of lower incidence. The data suggest that measures, such as malaria vaccines, that reduce parasite densities by limiting numbers of sporozoites reaching the liver, or merozoites released from the liver, will reduce malaria-associated morbidity and mortality, even when they do not prevent all infections.

Original languageEnglish
Pages (from-to)523-532
Number of pages10
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume51
Issue number5
StatePublished - Jan 1 1994
Externally publishedYes

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Parasitemia
Plasmodium falciparum
Culicidae
Malaria
Sporozoites
Parasites
Malaria Vaccines
Merozoites
Kenya
Liver
Incidence
Bites and Stings
Odds Ratio
Morbidity
Mortality
Infection

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Predicting outcome in malaria : Correlation between rate of exposure to infected mosquitoes and level of Plasmodium falciparum parasitemia. / McElroy, P. D.; Beier, John C; Oster, C. N.; Beadle, C.; Sherwood, J. A.; Oloo, A. J.; Hoffman, S. L.

In: American Journal of Tropical Medicine and Hygiene, Vol. 51, No. 5, 01.01.1994, p. 523-532.

Research output: Contribution to journalArticle

McElroy, P. D. ; Beier, John C ; Oster, C. N. ; Beadle, C. ; Sherwood, J. A. ; Oloo, A. J. ; Hoffman, S. L. / Predicting outcome in malaria : Correlation between rate of exposure to infected mosquitoes and level of Plasmodium falciparum parasitemia. In: American Journal of Tropical Medicine and Hygiene. 1994 ; Vol. 51, No. 5. pp. 523-532.
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