Predicting Occult Multifocality of Renal Cell Carcinoma

Matvey Tsivian, Daniel M. Moreira, Jorge R. Caso, Vladimir Mouraviev, John F. Madden, Gennady Bratslavsky, Cary N. Robertson, David M. Albala, Thomas J. Polascik

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Multifocal renal cell carcinoma (RCC) has been reported in up to 25% of all radical nephrectomy specimens. Modern imaging tends to underestimate the rate of multifocality. Recognition of multifocality before treatment may guide physicians and patients to the type of intervention and tailor long-term follow-up. Objective: Our aim was to develop and assess preoperative nomograms to predict occult multifocal RCC. Design, setting, and participants: We evaluated 560 consecutive patients undergoing radical nephrectomy for clinically localized suspected sporadic RCC between 2000 and 2008 in a tertiary center. Clinically manifest multifocal lesions were excluded. Logistic regression models were used to assess the potential risk factors of occult multifocality with and without pathologic variables that may be available with preoperative biopsy. Nomograms were developed and assessed for diagnostic properties. Interventions: All patients underwent radical nephrectomy. Measurements: Assessments of risk factors for occult multifocal RCC were obtained using regression models and nomograms. Results and limitations: The incidence of occult multifocality was 7.9%. Significantly associated predictors of multifocality were male gender, family history of malignancy other than RCC, radiographic size of the lesion, histologic subtype other than clear cell, and Fuhrman grade IV. The two designed nomograms had 0.75 and 0.82 concordance indices, respectively. Conclusions: Our data suggest that occult multifocal RCC is more frequently associated with small (2-4 cm) renal lesions. Male gender, family history of kidney cancer, histologic subtype, and grade are strongly associated with an increased risk of occult multifocal RCC. The developed nomograms had good predictive accuracy that was enhanced when combined with pathologic variables.

Original languageEnglish
Pages (from-to)118-126
Number of pages9
JournalEuropean Urology
Volume58
Issue number1
DOIs
StatePublished - Jul 1 2010

Fingerprint

Renal Cell Carcinoma
Nomograms
Nephrectomy
Logistic Models
Kidney Neoplasms
Physicians
Kidney
Biopsy
Incidence
Neoplasms

Keywords

  • Multicentricity
  • Multifocal
  • Nephron-sparing surgery
  • Occult
  • Partial nephrectomy
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

Tsivian, M., Moreira, D. M., Caso, J. R., Mouraviev, V., Madden, J. F., Bratslavsky, G., ... Polascik, T. J. (2010). Predicting Occult Multifocality of Renal Cell Carcinoma. European Urology, 58(1), 118-126. https://doi.org/10.1016/j.eururo.2010.03.011

Predicting Occult Multifocality of Renal Cell Carcinoma. / Tsivian, Matvey; Moreira, Daniel M.; Caso, Jorge R.; Mouraviev, Vladimir; Madden, John F.; Bratslavsky, Gennady; Robertson, Cary N.; Albala, David M.; Polascik, Thomas J.

In: European Urology, Vol. 58, No. 1, 01.07.2010, p. 118-126.

Research output: Contribution to journalArticle

Tsivian, M, Moreira, DM, Caso, JR, Mouraviev, V, Madden, JF, Bratslavsky, G, Robertson, CN, Albala, DM & Polascik, TJ 2010, 'Predicting Occult Multifocality of Renal Cell Carcinoma', European Urology, vol. 58, no. 1, pp. 118-126. https://doi.org/10.1016/j.eururo.2010.03.011
Tsivian M, Moreira DM, Caso JR, Mouraviev V, Madden JF, Bratslavsky G et al. Predicting Occult Multifocality of Renal Cell Carcinoma. European Urology. 2010 Jul 1;58(1):118-126. https://doi.org/10.1016/j.eururo.2010.03.011
Tsivian, Matvey ; Moreira, Daniel M. ; Caso, Jorge R. ; Mouraviev, Vladimir ; Madden, John F. ; Bratslavsky, Gennady ; Robertson, Cary N. ; Albala, David M. ; Polascik, Thomas J. / Predicting Occult Multifocality of Renal Cell Carcinoma. In: European Urology. 2010 ; Vol. 58, No. 1. pp. 118-126.
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abstract = "Background: Multifocal renal cell carcinoma (RCC) has been reported in up to 25{\%} of all radical nephrectomy specimens. Modern imaging tends to underestimate the rate of multifocality. Recognition of multifocality before treatment may guide physicians and patients to the type of intervention and tailor long-term follow-up. Objective: Our aim was to develop and assess preoperative nomograms to predict occult multifocal RCC. Design, setting, and participants: We evaluated 560 consecutive patients undergoing radical nephrectomy for clinically localized suspected sporadic RCC between 2000 and 2008 in a tertiary center. Clinically manifest multifocal lesions were excluded. Logistic regression models were used to assess the potential risk factors of occult multifocality with and without pathologic variables that may be available with preoperative biopsy. Nomograms were developed and assessed for diagnostic properties. Interventions: All patients underwent radical nephrectomy. Measurements: Assessments of risk factors for occult multifocal RCC were obtained using regression models and nomograms. Results and limitations: The incidence of occult multifocality was 7.9{\%}. Significantly associated predictors of multifocality were male gender, family history of malignancy other than RCC, radiographic size of the lesion, histologic subtype other than clear cell, and Fuhrman grade IV. The two designed nomograms had 0.75 and 0.82 concordance indices, respectively. Conclusions: Our data suggest that occult multifocal RCC is more frequently associated with small (2-4 cm) renal lesions. Male gender, family history of kidney cancer, histologic subtype, and grade are strongly associated with an increased risk of occult multifocal RCC. The developed nomograms had good predictive accuracy that was enhanced when combined with pathologic variables.",
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AU - Moreira, Daniel M.

AU - Caso, Jorge R.

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AU - Madden, John F.

AU - Bratslavsky, Gennady

AU - Robertson, Cary N.

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AB - Background: Multifocal renal cell carcinoma (RCC) has been reported in up to 25% of all radical nephrectomy specimens. Modern imaging tends to underestimate the rate of multifocality. Recognition of multifocality before treatment may guide physicians and patients to the type of intervention and tailor long-term follow-up. Objective: Our aim was to develop and assess preoperative nomograms to predict occult multifocal RCC. Design, setting, and participants: We evaluated 560 consecutive patients undergoing radical nephrectomy for clinically localized suspected sporadic RCC between 2000 and 2008 in a tertiary center. Clinically manifest multifocal lesions were excluded. Logistic regression models were used to assess the potential risk factors of occult multifocality with and without pathologic variables that may be available with preoperative biopsy. Nomograms were developed and assessed for diagnostic properties. Interventions: All patients underwent radical nephrectomy. Measurements: Assessments of risk factors for occult multifocal RCC were obtained using regression models and nomograms. Results and limitations: The incidence of occult multifocality was 7.9%. Significantly associated predictors of multifocality were male gender, family history of malignancy other than RCC, radiographic size of the lesion, histologic subtype other than clear cell, and Fuhrman grade IV. The two designed nomograms had 0.75 and 0.82 concordance indices, respectively. Conclusions: Our data suggest that occult multifocal RCC is more frequently associated with small (2-4 cm) renal lesions. Male gender, family history of kidney cancer, histologic subtype, and grade are strongly associated with an increased risk of occult multifocal RCC. The developed nomograms had good predictive accuracy that was enhanced when combined with pathologic variables.

KW - Multicentricity

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KW - Nephron-sparing surgery

KW - Occult

KW - Partial nephrectomy

KW - Renal cell carcinoma

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