Predicting change in symptoms of depression during the transition to university: The roles of BDNF and working memory capacity

Joelle LeMoult, Charles S Carver, Sheri L. Johnson, Jutta Joormann

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Studies on depression risk emphasize the importance of both cognitive and genetic vulnerability factors. The present study has provided the first examination of whether working memory capacity, the BDNF Val66Met polymorphism, and their interaction predict changes in symptoms of depression during the transition to university. Early in the semester, students completed a self-report measure of depressive symptoms and a modified version of the reading span task to assess working memory capacity in the presence of both neutral and negative distractors. Whole blood was genotyped for the BDNF Val66Met polymorphism. Students returned at the end of the semester to complete additional self-report questionnaires. Neither working memory capacity nor the BDNF Val66Met polymorphism predicted change in depressive symptoms either independently or in interaction with self-reported semester difficulty. The BDNF Val66Met polymorphism, however, moderated the association between working memory capacity and symptom change. Among met carriers, lower working memory capacity in the presence of negative-but not neutral-distractors was associated with increased symptoms of depression over the semester. For the val/val group, working memory capacity did not predict symptom change. These findings contribute directly to biological and cognitive models of depression and highlight the importance of examining Gene × Cognition interactions when investigating risk for depression.

Original languageEnglish
JournalCognitive, Affective, & Behavioral Neuroscience
DOIs
StateAccepted/In press - Jun 12 2014

Fingerprint

Brain-Derived Neurotrophic Factor
Short-Term Memory
Depression
Self Report
Students
Biological Models
Cognition
Reading
Genes

Keywords

  • Cognitive control
  • Depression
  • Gene-environment
  • Stress
  • Working memory

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

@article{d3978970794149e6976cf8332acd4e67,
title = "Predicting change in symptoms of depression during the transition to university: The roles of BDNF and working memory capacity",
abstract = "Studies on depression risk emphasize the importance of both cognitive and genetic vulnerability factors. The present study has provided the first examination of whether working memory capacity, the BDNF Val66Met polymorphism, and their interaction predict changes in symptoms of depression during the transition to university. Early in the semester, students completed a self-report measure of depressive symptoms and a modified version of the reading span task to assess working memory capacity in the presence of both neutral and negative distractors. Whole blood was genotyped for the BDNF Val66Met polymorphism. Students returned at the end of the semester to complete additional self-report questionnaires. Neither working memory capacity nor the BDNF Val66Met polymorphism predicted change in depressive symptoms either independently or in interaction with self-reported semester difficulty. The BDNF Val66Met polymorphism, however, moderated the association between working memory capacity and symptom change. Among met carriers, lower working memory capacity in the presence of negative-but not neutral-distractors was associated with increased symptoms of depression over the semester. For the val/val group, working memory capacity did not predict symptom change. These findings contribute directly to biological and cognitive models of depression and highlight the importance of examining Gene × Cognition interactions when investigating risk for depression.",
keywords = "Cognitive control, Depression, Gene-environment, Stress, Working memory",
author = "Joelle LeMoult and Carver, {Charles S} and Johnson, {Sheri L.} and Jutta Joormann",
year = "2014",
month = "6",
day = "12",
doi = "10.3758/s13415-014-0305-8",
language = "English",
journal = "Cognitive, Affective, & Behavioral Neuroscience",
issn = "1530-7026",
publisher = "Springer New York",

}

TY - JOUR

T1 - Predicting change in symptoms of depression during the transition to university

T2 - The roles of BDNF and working memory capacity

AU - LeMoult, Joelle

AU - Carver, Charles S

AU - Johnson, Sheri L.

AU - Joormann, Jutta

PY - 2014/6/12

Y1 - 2014/6/12

N2 - Studies on depression risk emphasize the importance of both cognitive and genetic vulnerability factors. The present study has provided the first examination of whether working memory capacity, the BDNF Val66Met polymorphism, and their interaction predict changes in symptoms of depression during the transition to university. Early in the semester, students completed a self-report measure of depressive symptoms and a modified version of the reading span task to assess working memory capacity in the presence of both neutral and negative distractors. Whole blood was genotyped for the BDNF Val66Met polymorphism. Students returned at the end of the semester to complete additional self-report questionnaires. Neither working memory capacity nor the BDNF Val66Met polymorphism predicted change in depressive symptoms either independently or in interaction with self-reported semester difficulty. The BDNF Val66Met polymorphism, however, moderated the association between working memory capacity and symptom change. Among met carriers, lower working memory capacity in the presence of negative-but not neutral-distractors was associated with increased symptoms of depression over the semester. For the val/val group, working memory capacity did not predict symptom change. These findings contribute directly to biological and cognitive models of depression and highlight the importance of examining Gene × Cognition interactions when investigating risk for depression.

AB - Studies on depression risk emphasize the importance of both cognitive and genetic vulnerability factors. The present study has provided the first examination of whether working memory capacity, the BDNF Val66Met polymorphism, and their interaction predict changes in symptoms of depression during the transition to university. Early in the semester, students completed a self-report measure of depressive symptoms and a modified version of the reading span task to assess working memory capacity in the presence of both neutral and negative distractors. Whole blood was genotyped for the BDNF Val66Met polymorphism. Students returned at the end of the semester to complete additional self-report questionnaires. Neither working memory capacity nor the BDNF Val66Met polymorphism predicted change in depressive symptoms either independently or in interaction with self-reported semester difficulty. The BDNF Val66Met polymorphism, however, moderated the association between working memory capacity and symptom change. Among met carriers, lower working memory capacity in the presence of negative-but not neutral-distractors was associated with increased symptoms of depression over the semester. For the val/val group, working memory capacity did not predict symptom change. These findings contribute directly to biological and cognitive models of depression and highlight the importance of examining Gene × Cognition interactions when investigating risk for depression.

KW - Cognitive control

KW - Depression

KW - Gene-environment

KW - Stress

KW - Working memory

UR - http://www.scopus.com/inward/record.url?scp=84902030192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902030192&partnerID=8YFLogxK

U2 - 10.3758/s13415-014-0305-8

DO - 10.3758/s13415-014-0305-8

M3 - Article

C2 - 24920443

AN - SCOPUS:84939877808

JO - Cognitive, Affective, & Behavioral Neuroscience

JF - Cognitive, Affective, & Behavioral Neuroscience

SN - 1530-7026

ER -