Precursor T-cell acute lymphoblastic leukemia in adults: Age-related immunophenotypic, cytogenetic, and molecular subsets

Mihaela Onciu, Raymond Lai, Francisco Vega, Carlos Bueso-Ramos, L. Jeffrey Medeiros

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We analyzed the clinicopathologic and molecular findings in 26 adults (age 16-72 years) with T-cell acute lymphoblastic leukemia (T-ALL) and observed features that correlated with age. Patients older than 60 years (n = 5) had a low frequency of hepatosplenomegaly (0 [0%]), anterior mediastinal mass (1 [20%]), and lymphadenopathy (2 [40%]), and completely responded to chemotherapy (4 of 4). The T-ALL in this group commonly expressed myeloid antigens (4 [80%]), had lineage-inappropriate gene rearrangements (2/3 [67%]) and chromosome 2 deletion (3/4 [75%]), and exclusively used the VIII, or VIVfamilies of the T-cell receptor (TCR) gamma gene. In comparison, patients 16 to 60 years old (n = 21) more commonly had an anterior mediastinal mass (8 [38%]), hepatosplenomegaly (10 [48%]), and lymphadenopathy (16 [76%]). The tumors in these patients commonly used the TCR gamma gene VI or VII families (17/25 total rearrangements [68%]). Myeloid antigen expression (5 [24%]) and lineage inappropriate gene rearrangements (4/15 [27%]) were uncommon. Within this group, CD1a expression correlated with age 28 to 60 years. These results illustrate considerable age-related heterogeneity in adult T-ALL, which may reflect differences in tumor cell maturation.

Original languageEnglish (US)
Pages (from-to)252-258
Number of pages7
JournalAmerican journal of clinical pathology
Volume117
Issue number2
DOIs
StatePublished - Aug 8 2002

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Keywords

  • Adults
  • Cytogenetics
  • Immunophenotype
  • Molecular studies
  • T-cell acute lymphoblastic leukemia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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