Preconditioning with bright light evokes a protective response against light damage in the rat retina

Changdong Liu, Min Peng, Alan M. Laties, Rong Wen

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Constant exposure to bright light induces photoreceptor degeneration and at the same time upregulates the expression of several neurotrophic factors in the retina. At issue is whether the induced neurotrophic factors protect photoreceptors. We used a preconditioning paradigm to show that animals preconditioned with bright light became resistant to subsequent light damage. The preconditioning consisted of a 12-48 hr preexposure, followed by a 48 hr 'rest phase' of normal cyclic lighting. The greatest protection was achieved by a 12 hr preexposure. Preconditioning induces a prolonged increase in two endogenous neurotrophic factors: basic fibroblast growth factor (bFGF) and ciliary neurotrophic factor (CNTF). It also stimulates the phosphorylation of extracellular signal-regulated protein kinases (Erks) in both photoreceptors and Muller cells. These findings indicate that exposure to bright light initiates two opposing processes: a fast degenerative process that kills photoreceptors and a relatively slower process that leads to the protection of photoreceptors. The extent of light damage, therefore, depends on the interaction of the two processes. These results also suggest a role of endogenous bFGF and CNTF in photoreceptor protection and the importance of Erk activation in photoreceptor survival.

Original languageEnglish
Pages (from-to)1337-1344
Number of pages8
JournalJournal of Neuroscience
Volume18
Issue number4
StatePublished - Feb 15 1998
Externally publishedYes

Fingerprint

Retina
Nerve Growth Factors
Light
Ciliary Neurotrophic Factor
Fibroblast Growth Factor 2
Ependymoglial Cells
Photoreceptor Cells
Extracellular Signal-Regulated MAP Kinases
Lighting
Protein Kinases
Up-Regulation
Phosphorylation

Keywords

  • bFGF
  • CNTF
  • Degeneration
  • Erk
  • Light damage
  • Muller cell
  • Photoreceptor
  • Rat
  • Retina

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Preconditioning with bright light evokes a protective response against light damage in the rat retina. / Liu, Changdong; Peng, Min; Laties, Alan M.; Wen, Rong.

In: Journal of Neuroscience, Vol. 18, No. 4, 15.02.1998, p. 1337-1344.

Research output: Contribution to journalArticle

Liu, Changdong ; Peng, Min ; Laties, Alan M. ; Wen, Rong. / Preconditioning with bright light evokes a protective response against light damage in the rat retina. In: Journal of Neuroscience. 1998 ; Vol. 18, No. 4. pp. 1337-1344.
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