Preconditioning for Traumatic Brain Injury

Shoji Yokobori, Anna T. Mazzeo, Khadil Hosein, Shyam Gajavelli, W. Dalton Dietrich, Ross Bullock

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) treatment is now focused on the prevention of primary injury and reduction of secondary injury. However, no single effective treatment is available as yet for the mitigation of traumatic brain damage in humans. Both chemical and environmental stresses applied before injury have been shown to induce consequent protection against post-TBI neuronal death. This concept termed "preconditioning" is achieved by exposure to different pre-injury stressors to achieve the induction of "tolerance" to the effect of the TBI. However, the precise mechanisms underlying this "tolerance" phenomenon are not fully understood in TBI, and therefore even less information is available about possible indications in clinical TBI patients. In this review, we will summarize TBI pathophysiology, and discuss existing animal studies demonstrating the efficacy of preconditioning in diffuse and focal type of TBI. We will also review other non-TBI preconditioning studies, including ischemic, environmental, and chemical preconditioning, which maybe relevant to TBI. To date, no clinical studies exist in this field, and we speculate on possible future clinical situations, in which pre-TBI preconditioning could be considered.

Original languageEnglish
Pages (from-to)25-39
Number of pages15
JournalTranslational Stroke Research
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Wounds and Injuries
Brain Injuries
Traumatic Brain Injury
Primary Prevention
Brain
Therapeutics
Clinical Studies

Keywords

  • Neuroprotection
  • Pathophysiology
  • Preconditioning
  • Traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Yokobori, S., Mazzeo, A. T., Hosein, K., Gajavelli, S., Dalton Dietrich, W., & Bullock, R. (2013). Preconditioning for Traumatic Brain Injury. Translational Stroke Research, 4(1), 25-39. https://doi.org/10.1007/s12975-012-0226-1

Preconditioning for Traumatic Brain Injury. / Yokobori, Shoji; Mazzeo, Anna T.; Hosein, Khadil; Gajavelli, Shyam; Dalton Dietrich, W.; Bullock, Ross.

In: Translational Stroke Research, Vol. 4, No. 1, 01.01.2013, p. 25-39.

Research output: Contribution to journalArticle

Yokobori, S, Mazzeo, AT, Hosein, K, Gajavelli, S, Dalton Dietrich, W & Bullock, R 2013, 'Preconditioning for Traumatic Brain Injury', Translational Stroke Research, vol. 4, no. 1, pp. 25-39. https://doi.org/10.1007/s12975-012-0226-1
Yokobori, Shoji ; Mazzeo, Anna T. ; Hosein, Khadil ; Gajavelli, Shyam ; Dalton Dietrich, W. ; Bullock, Ross. / Preconditioning for Traumatic Brain Injury. In: Translational Stroke Research. 2013 ; Vol. 4, No. 1. pp. 25-39.
@article{606db8eaa8334f3db8d3f65f86668d40,
title = "Preconditioning for Traumatic Brain Injury",
abstract = "Traumatic brain injury (TBI) treatment is now focused on the prevention of primary injury and reduction of secondary injury. However, no single effective treatment is available as yet for the mitigation of traumatic brain damage in humans. Both chemical and environmental stresses applied before injury have been shown to induce consequent protection against post-TBI neuronal death. This concept termed {"}preconditioning{"} is achieved by exposure to different pre-injury stressors to achieve the induction of {"}tolerance{"} to the effect of the TBI. However, the precise mechanisms underlying this {"}tolerance{"} phenomenon are not fully understood in TBI, and therefore even less information is available about possible indications in clinical TBI patients. In this review, we will summarize TBI pathophysiology, and discuss existing animal studies demonstrating the efficacy of preconditioning in diffuse and focal type of TBI. We will also review other non-TBI preconditioning studies, including ischemic, environmental, and chemical preconditioning, which maybe relevant to TBI. To date, no clinical studies exist in this field, and we speculate on possible future clinical situations, in which pre-TBI preconditioning could be considered.",
keywords = "Neuroprotection, Pathophysiology, Preconditioning, Traumatic brain injury",
author = "Shoji Yokobori and Mazzeo, {Anna T.} and Khadil Hosein and Shyam Gajavelli and {Dalton Dietrich}, W. and Ross Bullock",
year = "2013",
month = "1",
day = "1",
doi = "10.1007/s12975-012-0226-1",
language = "English",
volume = "4",
pages = "25--39",
journal = "Translational Stroke Research",
issn = "1868-4483",
publisher = "Springer US",
number = "1",

}

TY - JOUR

T1 - Preconditioning for Traumatic Brain Injury

AU - Yokobori, Shoji

AU - Mazzeo, Anna T.

AU - Hosein, Khadil

AU - Gajavelli, Shyam

AU - Dalton Dietrich, W.

AU - Bullock, Ross

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Traumatic brain injury (TBI) treatment is now focused on the prevention of primary injury and reduction of secondary injury. However, no single effective treatment is available as yet for the mitigation of traumatic brain damage in humans. Both chemical and environmental stresses applied before injury have been shown to induce consequent protection against post-TBI neuronal death. This concept termed "preconditioning" is achieved by exposure to different pre-injury stressors to achieve the induction of "tolerance" to the effect of the TBI. However, the precise mechanisms underlying this "tolerance" phenomenon are not fully understood in TBI, and therefore even less information is available about possible indications in clinical TBI patients. In this review, we will summarize TBI pathophysiology, and discuss existing animal studies demonstrating the efficacy of preconditioning in diffuse and focal type of TBI. We will also review other non-TBI preconditioning studies, including ischemic, environmental, and chemical preconditioning, which maybe relevant to TBI. To date, no clinical studies exist in this field, and we speculate on possible future clinical situations, in which pre-TBI preconditioning could be considered.

AB - Traumatic brain injury (TBI) treatment is now focused on the prevention of primary injury and reduction of secondary injury. However, no single effective treatment is available as yet for the mitigation of traumatic brain damage in humans. Both chemical and environmental stresses applied before injury have been shown to induce consequent protection against post-TBI neuronal death. This concept termed "preconditioning" is achieved by exposure to different pre-injury stressors to achieve the induction of "tolerance" to the effect of the TBI. However, the precise mechanisms underlying this "tolerance" phenomenon are not fully understood in TBI, and therefore even less information is available about possible indications in clinical TBI patients. In this review, we will summarize TBI pathophysiology, and discuss existing animal studies demonstrating the efficacy of preconditioning in diffuse and focal type of TBI. We will also review other non-TBI preconditioning studies, including ischemic, environmental, and chemical preconditioning, which maybe relevant to TBI. To date, no clinical studies exist in this field, and we speculate on possible future clinical situations, in which pre-TBI preconditioning could be considered.

KW - Neuroprotection

KW - Pathophysiology

KW - Preconditioning

KW - Traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=84872665202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872665202&partnerID=8YFLogxK

U2 - 10.1007/s12975-012-0226-1

DO - 10.1007/s12975-012-0226-1

M3 - Article

C2 - 24323189

AN - SCOPUS:84872665202

VL - 4

SP - 25

EP - 39

JO - Translational Stroke Research

JF - Translational Stroke Research

SN - 1868-4483

IS - 1

ER -