Preclinical Studies of Stem Cell Therapy for Heart Disease

Bryon A. Tompkins, Wayne Balkan, Johannes Winkler, Mariann Gyöngyösi, Georg Goliasch, Francisco Fernández-Avilés, Joshua M. Hare

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


As part of the TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) series to enhance regenerative medicine, here, we discuss the role of preclinical studies designed to advance stem cell therapies for cardiovascular disease. The quality of this research has improved over the past 10 to 15 years and overall indicates that cell therapy promotes cardiac repair. However, many issues remain, including inability to provide complete cardiac recovery. Recent studies question the need for intact cells suggesting that harnessing what the cells release is the solution. Our contribution describes important breakthroughs and current directions in a cell-based approach to alleviating cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)1006-1020
Number of pages15
JournalCirculation research
Issue number7
StatePublished - Mar 30 2018


  • heart failure
  • infarction
  • regenerative medicine
  • stem cells

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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