Abstract
Cutaneous wound healing is an evolutionarily conserved and highly complex process that restores the cutaneous barrier after injury. Experimental wound-healing models provide great advantages to study mechanisms that control this intricate process. In addition, they provide a useful platform to evaluate novel therapies with the goal of translation to patient care. In vitro, ex vivo, and in vivo assays are all very useful for preclinical studies, and each has its own unique set of advantages. However, these models also come with their own distinct limitations particularly as they relate to translatability to clinical practice. This is especially true for chronic wounds, for which no optimal preclinical model exists. Chronic wounds result from a composite dysregulation of multiple local and systemic processes that contribute to the wound-healing process, including underlying conditions such as vascular disease, diabetes, and aging that are difficult to replicate in any given model. Here, we describe the most current in vitro and in vivo models for wound-healing studies with a focus on their advantages and disadvantages and recent advances that are promising for the future of wound-healing research.
| Original language | English (US) |
|---|---|
| Title of host publication | Skin Tissue Models |
| Publisher | Elsevier Inc. |
| Pages | 223-251 |
| Number of pages | 29 |
| ISBN (Electronic) | 9780128110003 |
| ISBN (Print) | 9780128105450 |
| DOIs | |
| State | Published - Nov 15 2017 |
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Keywords
- Animal wound models
- Cell migration
- Chronic wounds
- Fibroblasts
- Keratinocytes
- The organotypic skin
- Wound healing
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Preclinical models for wound-healing studies. / Pastar, Irena; Liang, Liang; Sawaya, Andrew P.; Wikramanayake, Tongyu; Glinos, George D.; Drakulich, Stefan; Chen, Vivien; Stojadinovic, Olivera; Davis, Stephen C; Tomic-Canic, Marjana.
Skin Tissue Models. Elsevier Inc., 2017. p. 223-251.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Preclinical models for wound-healing studies
AU - Pastar, Irena
AU - Liang, Liang
AU - Sawaya, Andrew P.
AU - Wikramanayake, Tongyu
AU - Glinos, George D.
AU - Drakulich, Stefan
AU - Chen, Vivien
AU - Stojadinovic, Olivera
AU - Davis, Stephen C
AU - Tomic-Canic, Marjana
PY - 2017/11/15
Y1 - 2017/11/15
N2 - Cutaneous wound healing is an evolutionarily conserved and highly complex process that restores the cutaneous barrier after injury. Experimental wound-healing models provide great advantages to study mechanisms that control this intricate process. In addition, they provide a useful platform to evaluate novel therapies with the goal of translation to patient care. In vitro, ex vivo, and in vivo assays are all very useful for preclinical studies, and each has its own unique set of advantages. However, these models also come with their own distinct limitations particularly as they relate to translatability to clinical practice. This is especially true for chronic wounds, for which no optimal preclinical model exists. Chronic wounds result from a composite dysregulation of multiple local and systemic processes that contribute to the wound-healing process, including underlying conditions such as vascular disease, diabetes, and aging that are difficult to replicate in any given model. Here, we describe the most current in vitro and in vivo models for wound-healing studies with a focus on their advantages and disadvantages and recent advances that are promising for the future of wound-healing research.
AB - Cutaneous wound healing is an evolutionarily conserved and highly complex process that restores the cutaneous barrier after injury. Experimental wound-healing models provide great advantages to study mechanisms that control this intricate process. In addition, they provide a useful platform to evaluate novel therapies with the goal of translation to patient care. In vitro, ex vivo, and in vivo assays are all very useful for preclinical studies, and each has its own unique set of advantages. However, these models also come with their own distinct limitations particularly as they relate to translatability to clinical practice. This is especially true for chronic wounds, for which no optimal preclinical model exists. Chronic wounds result from a composite dysregulation of multiple local and systemic processes that contribute to the wound-healing process, including underlying conditions such as vascular disease, diabetes, and aging that are difficult to replicate in any given model. Here, we describe the most current in vitro and in vivo models for wound-healing studies with a focus on their advantages and disadvantages and recent advances that are promising for the future of wound-healing research.
KW - Animal wound models
KW - Cell migration
KW - Chronic wounds
KW - Fibroblasts
KW - Keratinocytes
KW - The organotypic skin
KW - Wound healing
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UR - http://www.scopus.com/inward/citedby.url?scp=85042607504&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-810545-0.00010-3
DO - 10.1016/B978-0-12-810545-0.00010-3
M3 - Chapter
SN - 9780128105450
SP - 223
EP - 251
BT - Skin Tissue Models
PB - Elsevier Inc.
ER -