TY - CHAP
T1 - Precision Psychiatry
T2 - Biomarker-Guided Tailored Therapy for Effective Treatment and Prevention in Major Depression
AU - Jones, Candace
AU - Nemeroff, Charles B.
N1 - Publisher Copyright:
© 2021, Springer Nature Singapore Pte Ltd.
PY - 2021
Y1 - 2021
N2 - Depression contributes greatly to global disability and is a leading cause of suicide. It has multiple etiologies and therefore response to treatment can vary significantly. By applying the concepts of personalized medicine, precision psychiatry attempts to optimize psychiatric patient care by better predicting which individuals will develop an illness, by giving a more accurate biologically based diagnosis, and by utilizing more effective treatments based on an individual’s biological characteristics (biomarkers). In this chapter, we discuss the basic principles underlying the role of biomarkers in psychiatric pathology and then explore multiple biomarkers that are specific to depression. These include endophenotypes, gene variants/polymorphisms, epigenetic factors such as methylation, biochemical measures, circadian rhythm dysregulation, and neuroimaging findings. We also examine the role of early childhood trauma in the development of, and treatment response to, depression. In addition, we review how new developments in technology may play a greater role in the determination of new biomarkers for depression.
AB - Depression contributes greatly to global disability and is a leading cause of suicide. It has multiple etiologies and therefore response to treatment can vary significantly. By applying the concepts of personalized medicine, precision psychiatry attempts to optimize psychiatric patient care by better predicting which individuals will develop an illness, by giving a more accurate biologically based diagnosis, and by utilizing more effective treatments based on an individual’s biological characteristics (biomarkers). In this chapter, we discuss the basic principles underlying the role of biomarkers in psychiatric pathology and then explore multiple biomarkers that are specific to depression. These include endophenotypes, gene variants/polymorphisms, epigenetic factors such as methylation, biochemical measures, circadian rhythm dysregulation, and neuroimaging findings. We also examine the role of early childhood trauma in the development of, and treatment response to, depression. In addition, we review how new developments in technology may play a greater role in the determination of new biomarkers for depression.
KW - Biomarkers
KW - Depression
KW - Endophenotypes
KW - Epigenetics
KW - Genetics
KW - Neuroimaging
KW - Precision psychiatry
UR - http://www.scopus.com/inward/record.url?scp=85104125076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85104125076&partnerID=8YFLogxK
U2 - 10.1007/978-981-33-6044-0_27
DO - 10.1007/978-981-33-6044-0_27
M3 - Chapter
C2 - 33834417
AN - SCOPUS:85104125076
T3 - Advances in Experimental Medicine and Biology
SP - 535
EP - 563
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -
