Pre-treatment testosterone levels: Significance in androgen deprivation therapy

D. Hickey, B. Todd, M. S. Soloway

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

From June 1982 to February 1985, 53 patients with stage D2 carcinoma of the prostate confirmed by tissue biopsy, elevated prostatic acid phosphatase and a positive bone scan were initiated on androgen deprivation therapy. Before commencement of treatment all patients underwent determination of serum testosterone levels at 8 a.m. Of the patients 23 received 200 mcg buserelin per day, 17 received 1 mg diethylstilbestrol 3 times daily, 6 received 40 mg megestrol acetate 4 times daily, 2 received 1 mg leuprolide per day and 5 underwent bilateral orchiectomy. Evaluation of the best response in each patient revealed 3 (6 per cent) complete and 17 (32 per cent) partial responses, while 22 patients (41 per cent) remained stable and 11 (21 per cent) had progression. Pre-treatment serum testosterone levels ranged from 150 to 879 ng per dl. The mean serum testosterone level in patients having a complete response was 524 ± 18.04 ng per dl. The mean in the progression group was 279.4 ± 110.1 ng per dl. This difference was not statistically significant owing to the large standard deviation in the progression group. However, of the 15 patients who had a pre-treatment serum testosterone level of more than 500 ng per dl only 1 (7 per cent) had progression. None of the patients whose pre-treatment testosterone level was less than 200 ng per dl had objective tumor regression. Our study suggests that pre-treatment serum testosterone levels may predict the probability of a satisfactory response to androgen deprivation therapy.

Original languageEnglish (US)
Pages (from-to)1038-1040
Number of pages3
JournalJournal of Urology
Volume136
Issue number5
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Pre-treatment testosterone levels: Significance in androgen deprivation therapy'. Together they form a unique fingerprint.

  • Cite this