Pre-exposure prophylaxis uptake and discontinuation among young black men who have sex with men in atlanta, Georgia: A prospective cohort study

David P. Serota, Eli S. Rosenberg, Patrick S. Sullivan, Annie L. Thorne, Charlotte Paige M. Rolle, Carlos Del Rio, Scott Cutro, Nicole Luisi, Aaron J. Siegler, Travis H. Sanchez, Colleen F. Kelley

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Background. Human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) has great potential to reduce HIV incidence among young black men who have sex with men (YBMSM); however, initiation and persistence for this group remain low. We sought to understand the patterns and predictors of PrEP uptake and discontinuation among YBMSM in Atlanta, Georgia. Methods. PrEP was offered to all participants in a prospective cohort of YBMSM aged 18-29 years not living with HIV. Time to PrEP uptake, first discontinuation, and final discontinuation were assessed using the Kaplan-Meier method. Cox proportional hazard models were used to identify predictors of uptake and discontinuation. Results. After 440 person-years of follow-up, 44% of YBMSM initiated PrEP through the study after a median of 122 days. Of PrEP initiators, 69% had a first discontinuation and 40% had a final discontinuation during the study period. The median time to first PrEP discontinuation was 159 days. Factors associated with PrEP uptake included higher self-efficacy, sexually transmitted infection (STI), and condomless anal intercourse. Factors associated with discontinuation included younger age, cannabis use, STI, and fewer sex partners. HIV incidence was 5.23/100 person-years (95% confidence interval [CI], 3.40-7.23), with a lower rate among those who started PrEP (incidence rate ratio, 0.39; 95% CI, .16-.92). Conclusions. Persistent PrEP coverage in this cohort of YBMSM was suboptimal, and discontinuations were common despite additional support services available through the study. Interventions to support PrEP uptake and persistence, especially for younger and substance-using YBMSM, are necessary to achieve full PrEP effectiveness.

Original languageEnglish (US)
Pages (from-to)574-582
Number of pages9
JournalClinical Infectious Diseases
Issue number3
StatePublished - Aug 1 2020
Externally publishedYes


  • Cannabis use
  • MSM
  • PrEP
  • Substance use
  • Young black men who have sex with men

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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