Pre-existing undiagnosed central diabetes insipidus unmasked after renal transplantation

Jerson Munoz-Mendoza, Veronica Pinto Miranda, Warren L. Kupin

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Central diabetes insipidus (CDI) is characterized clinically by the presence of polyuria with the subsequent development of volume depletion and hypernatremia. In patients with dialysis-dependent end-stage renal disease (ESRD), neither of these findings can be expressed due to the absence of renal function. A 59-year-old woman with anuric ESRD of unknown etiology had been on peritoneal dialysis for 8 years prior to receiving a cadaveric allograft. Postoperatively, she developed persistent polyuria and hypernatremia. A desmopressin test confirmed the diagnosis of CDI. A magnetic resonance imaging (MRI) of the brain revealed an empty sella turcica. Maintenance therapy with intranasal desmopressin resulted in complete resolution of the polyuria. At 6-month follow-up on daily desmopressin, the patient maintains normal serum sodium levels and stable allograft function. This is a unique case of CDI from empty sella syndrome (ESS) that was unmasked only after the restoration of normal renal function following successful renal transplantation.

Original languageEnglish (US)
Pages (from-to)81-83
Number of pages3
JournalClinical Kidney Journal
Issue number1
StatePublished - Feb 2013


  • central diabetes insipidus
  • empty sella syndrome
  • end-stage kidney disease
  • renal transplantation

ASJC Scopus subject areas

  • Nephrology
  • Transplantation


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