Pre-existing undiagnosed central diabetes insipidus unmasked after renal transplantation

Jerson Munoz-Mendoza, Veronica Pinto Miranda, Warren Kupin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Central diabetes insipidus (CDI) is characterized clinically by the presence of polyuria with the subsequent development of volume depletion and hypernatremia. In patients with dialysis-dependent end-stage renal disease (ESRD), neither of these findings can be expressed due to the absence of renal function. A 59-year-old woman with anuric ESRD of unknown etiology had been on peritoneal dialysis for 8 years prior to receiving a cadaveric allograft. Postoperatively, she developed persistent polyuria and hypernatremia. A desmopressin test confirmed the diagnosis of CDI. A magnetic resonance imaging (MRI) of the brain revealed an empty sella turcica. Maintenance therapy with intranasal desmopressin resulted in complete resolution of the polyuria. At 6-month follow-up on daily desmopressin, the patient maintains normal serum sodium levels and stable allograft function. This is a unique case of CDI from empty sella syndrome (ESS) that was unmasked only after the restoration of normal renal function following successful renal transplantation.

Original languageEnglish
Pages (from-to)81-83
Number of pages3
JournalClinical Kidney Journal
Volume6
Issue number1
DOIs
StatePublished - Feb 1 2013

Fingerprint

Neurogenic Diabetes Insipidus
Polyuria
Deamino Arginine Vasopressin
Empty Sella Syndrome
Kidney Transplantation
Hypernatremia
Chronic Kidney Failure
Allografts
Kidney
Peritoneal Dialysis
Dialysis
Sodium
Magnetic Resonance Imaging
Brain
Serum
Therapeutics

Keywords

  • central diabetes insipidus
  • empty sella syndrome
  • end-stage kidney disease
  • renal transplantation

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Pre-existing undiagnosed central diabetes insipidus unmasked after renal transplantation. / Munoz-Mendoza, Jerson; Pinto Miranda, Veronica; Kupin, Warren.

In: Clinical Kidney Journal, Vol. 6, No. 1, 01.02.2013, p. 81-83.

Research output: Contribution to journalArticle

Munoz-Mendoza, Jerson ; Pinto Miranda, Veronica ; Kupin, Warren. / Pre-existing undiagnosed central diabetes insipidus unmasked after renal transplantation. In: Clinical Kidney Journal. 2013 ; Vol. 6, No. 1. pp. 81-83.
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