Pre-existing and Postoperative Intimal Hyperplasia and Arteriovenous Fistula Outcomes

Marwan Tabbara, Juan C. Duque, Laisel Martinez, Luis A. Escobar, Wensong Wu, Yue Pan, Natasha Fernandez, Omaida C Velazquez, Edgar A. Jaimes, Loay Salman, Roberto I Vazquez-Padron

Research output: Contribution to journalArticle

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Abstract

Background: The contribution of intimal hyperplasia (IH) to arteriovenous fistula (AVF) failure is uncertain. This observational study assessed the relationship between pre-existing, postoperative, and change in IH over time and AVF outcomes. Study Design: Prospective cohort study with longitudinal assessment of IH at the time of AVF creation (pre-existing) and transposition (postoperative). Patients were followed up for up to 3.3 years. Setting & Participants: 96 patients from a single center who underwent AVF surgery initially planned as a 2-stage procedure. Veins and AVF samples were collected from 66 and 86 patients, respectively. Matched-pair tissues were available from 56 of these patients. Predictors: Pre-existing, postoperative, and change in IH over time. Outcomes: Anatomic maturation failure was defined as an AVF that never reached a diameter > 6. mm. Primary unassisted patency was defined as the time elapsed from the second-stage surgery to the first intervention. Measurements: Maximal intimal thickness in veins and AVFs and change in intimal thickness over time. Results: Pre-existing IH (>0.05mm) was present in 98% of patients. In this group, the median intimal thickness increased 4.40-fold (IQR, 2.17- to 4.94-fold) between AVF creation and transposition. However, this change was not associated with pre-existing thickness (r 2 =0.002; P =0.7). Ten of 96 (10%) AVFs never achieved maturation, whereas 70% of vascular accesses remained patent at the end of the observational period. Postoperative IH was not associated with anatomic maturation failure using univariate logistic regression. Pre-existing, postoperative, and change in IH over time had no effects on primary unassisted patency. Limitations: The small number of patients from whom longitudinal tissue samples were available and low incidence of anatomic maturation failure, which decreased the statistical power to find associations between end points and IH. Conclusions: Pre-existing, postoperative, and change in IH over time were not associated with 2-stage AVF outcomes.

Original languageEnglish (US)
JournalAmerican Journal of Kidney Diseases
DOIs
StateAccepted/In press - Sep 2 2015

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Tunica Intima
Arteriovenous Fistula
Hyperplasia
Veins
Observational Studies
Blood Vessels

Keywords

  • Anatomic maturation failure
  • Arteriovenous fistula (AVF)
  • AVF creation
  • AVF transposition
  • End-stage renal disease (ESRD)
  • Failure
  • Hemodialysis
  • Histology
  • Intimal hyperplasia (IH)
  • Intimal thickness
  • Outcomes
  • Primary unassisted patency
  • Stenosis
  • Vascular access
  • Vascular pathology

ASJC Scopus subject areas

  • Nephrology

Cite this

Pre-existing and Postoperative Intimal Hyperplasia and Arteriovenous Fistula Outcomes. / Tabbara, Marwan; Duque, Juan C.; Martinez, Laisel; Escobar, Luis A.; Wu, Wensong; Pan, Yue; Fernandez, Natasha; Velazquez, Omaida C; Jaimes, Edgar A.; Salman, Loay; Vazquez-Padron, Roberto I.

In: American Journal of Kidney Diseases, 02.09.2015.

Research output: Contribution to journalArticle

Tabbara, Marwan ; Duque, Juan C. ; Martinez, Laisel ; Escobar, Luis A. ; Wu, Wensong ; Pan, Yue ; Fernandez, Natasha ; Velazquez, Omaida C ; Jaimes, Edgar A. ; Salman, Loay ; Vazquez-Padron, Roberto I. / Pre-existing and Postoperative Intimal Hyperplasia and Arteriovenous Fistula Outcomes. In: American Journal of Kidney Diseases. 2015.
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keywords = "Anatomic maturation failure, Arteriovenous fistula (AVF), AVF creation, AVF transposition, End-stage renal disease (ESRD), Failure, Hemodialysis, Histology, Intimal hyperplasia (IH), Intimal thickness, Outcomes, Primary unassisted patency, Stenosis, Vascular access, Vascular pathology",
author = "Marwan Tabbara and Duque, {Juan C.} and Laisel Martinez and Escobar, {Luis A.} and Wensong Wu and Yue Pan and Natasha Fernandez and Velazquez, {Omaida C} and Jaimes, {Edgar A.} and Loay Salman and Vazquez-Padron, {Roberto I}",
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AU - Tabbara, Marwan

AU - Duque, Juan C.

AU - Martinez, Laisel

AU - Escobar, Luis A.

AU - Wu, Wensong

AU - Pan, Yue

AU - Fernandez, Natasha

AU - Velazquez, Omaida C

AU - Jaimes, Edgar A.

AU - Salman, Loay

AU - Vazquez-Padron, Roberto I

PY - 2015/9/2

Y1 - 2015/9/2

N2 - Background: The contribution of intimal hyperplasia (IH) to arteriovenous fistula (AVF) failure is uncertain. This observational study assessed the relationship between pre-existing, postoperative, and change in IH over time and AVF outcomes. Study Design: Prospective cohort study with longitudinal assessment of IH at the time of AVF creation (pre-existing) and transposition (postoperative). Patients were followed up for up to 3.3 years. Setting & Participants: 96 patients from a single center who underwent AVF surgery initially planned as a 2-stage procedure. Veins and AVF samples were collected from 66 and 86 patients, respectively. Matched-pair tissues were available from 56 of these patients. Predictors: Pre-existing, postoperative, and change in IH over time. Outcomes: Anatomic maturation failure was defined as an AVF that never reached a diameter > 6. mm. Primary unassisted patency was defined as the time elapsed from the second-stage surgery to the first intervention. Measurements: Maximal intimal thickness in veins and AVFs and change in intimal thickness over time. Results: Pre-existing IH (>0.05mm) was present in 98% of patients. In this group, the median intimal thickness increased 4.40-fold (IQR, 2.17- to 4.94-fold) between AVF creation and transposition. However, this change was not associated with pre-existing thickness (r 2 =0.002; P =0.7). Ten of 96 (10%) AVFs never achieved maturation, whereas 70% of vascular accesses remained patent at the end of the observational period. Postoperative IH was not associated with anatomic maturation failure using univariate logistic regression. Pre-existing, postoperative, and change in IH over time had no effects on primary unassisted patency. Limitations: The small number of patients from whom longitudinal tissue samples were available and low incidence of anatomic maturation failure, which decreased the statistical power to find associations between end points and IH. Conclusions: Pre-existing, postoperative, and change in IH over time were not associated with 2-stage AVF outcomes.

AB - Background: The contribution of intimal hyperplasia (IH) to arteriovenous fistula (AVF) failure is uncertain. This observational study assessed the relationship between pre-existing, postoperative, and change in IH over time and AVF outcomes. Study Design: Prospective cohort study with longitudinal assessment of IH at the time of AVF creation (pre-existing) and transposition (postoperative). Patients were followed up for up to 3.3 years. Setting & Participants: 96 patients from a single center who underwent AVF surgery initially planned as a 2-stage procedure. Veins and AVF samples were collected from 66 and 86 patients, respectively. Matched-pair tissues were available from 56 of these patients. Predictors: Pre-existing, postoperative, and change in IH over time. Outcomes: Anatomic maturation failure was defined as an AVF that never reached a diameter > 6. mm. Primary unassisted patency was defined as the time elapsed from the second-stage surgery to the first intervention. Measurements: Maximal intimal thickness in veins and AVFs and change in intimal thickness over time. Results: Pre-existing IH (>0.05mm) was present in 98% of patients. In this group, the median intimal thickness increased 4.40-fold (IQR, 2.17- to 4.94-fold) between AVF creation and transposition. However, this change was not associated with pre-existing thickness (r 2 =0.002; P =0.7). Ten of 96 (10%) AVFs never achieved maturation, whereas 70% of vascular accesses remained patent at the end of the observational period. Postoperative IH was not associated with anatomic maturation failure using univariate logistic regression. Pre-existing, postoperative, and change in IH over time had no effects on primary unassisted patency. Limitations: The small number of patients from whom longitudinal tissue samples were available and low incidence of anatomic maturation failure, which decreased the statistical power to find associations between end points and IH. Conclusions: Pre-existing, postoperative, and change in IH over time were not associated with 2-stage AVF outcomes.

KW - Anatomic maturation failure

KW - Arteriovenous fistula (AVF)

KW - AVF creation

KW - AVF transposition

KW - End-stage renal disease (ESRD)

KW - Failure

KW - Hemodialysis

KW - Histology

KW - Intimal hyperplasia (IH)

KW - Intimal thickness

KW - Outcomes

KW - Primary unassisted patency

KW - Stenosis

KW - Vascular access

KW - Vascular pathology

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