Prazosin and renal hemodynamics: Arteriolar vasodilation during therapy of essential hypertension in man

Richard A. Preston, Daniel T. O’Connor, Richard A. Stone

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33 Scopus citations


Renal hemodynamic effects of chronic prazosin therapy were studied in 10 men with essential hypertension. Successful antihypertensive therapy was accompanied by diminution in total renovascular resistance, probably at the level of the afferent arteriole. The resistance change was unexplained by alterations in intravascular volume, the vasodilatory renal kallikrein-kinin system, or sympathetic nervous sytem activity, but was associated with a diminution in plasma renin activity. Potential mechanisms for the resistance decrement are discussed, including renal perfusion autoregulation, diminished activity of the vasoconstrictive renin-angiotensin system, and direct intrarenal afferent arteriolar alpha adrenergic blockade.

Original languageEnglish (US)
Pages (from-to)277-286
Number of pages10
JournalJournal of Cardiovascular Pharmacology
Issue number3
StatePublished - Jan 1 1979
Externally publishedYes



  • Essential hypertension
  • Prazosin
  • Renal hemodynamics

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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