Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma

Owen A. O'Connor, Paul A. Hamlin, Carol Portlock, Craig Moskowitz, Ariela Noy, David J. Straus, Barbara MacGregor-Cortelli, Ellen Neylon, Debra Sarasohn, Otila Dumetrescu, Diane R. Mould, Martin Fleischer, Andrew D. Zelenetz, Frank Sirotnak, Steven Horwitz

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

T-cell lymphomas (TCLs) are characterised by poor responses to therapy with brief durations of remissions. An early phase study of pralatrexate has demonstrated dramatic activity in patients with relapsed/refractory disease. Of the first 20 lymphoma patients treated, 16 had B-cell lymphoma and four had refractory aggressive TCL. All four patients with TCL achieved a complete remission. Patients with B-cell lymphoma achieved stable disease at best. For each TCL patient, the response was more durable than their best response with chemotherapy. This early experience is the first to document this unique activity of pralatrexate in TCL.

Original languageEnglish (US)
Pages (from-to)425-428
Number of pages4
JournalBritish Journal of Haematology
Volume139
Issue number3
DOIs
StatePublished - Nov 1 2007
Externally publishedYes

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Keywords

  • Antifolate
  • Pralatrexate
  • Reduced folate carrier
  • T-cell lymphoma

ASJC Scopus subject areas

  • Hematology

Cite this

O'Connor, O. A., Hamlin, P. A., Portlock, C., Moskowitz, C., Noy, A., Straus, D. J., MacGregor-Cortelli, B., Neylon, E., Sarasohn, D., Dumetrescu, O., Mould, D. R., Fleischer, M., Zelenetz, A. D., Sirotnak, F., & Horwitz, S. (2007). Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma. British Journal of Haematology, 139(3), 425-428. https://doi.org/10.1111/j.1365-2141.2007.06658.x