Practice Patterns of Radiotherapy in Cervical Cancer Among Member Groups of the Gynecologic Cancer Intergroup (GCIG)

David K. Gaffney, Andreas Du Bois, Kailash Narayan, Nick Reed, Takafumi Toita, Sandro Pignata, Peter Blake, Lorraine Portelance, Azmat Sadoyze, Richard Pötter, Alessandro Colombo, Marcus Randall, Mansoor R. Mirza, Edward L. Trimble

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose: The aim of this study was to describe radiotherapeutic practice of the treatment of cervical cancer in member groups of the Gynecologic Cancer Intergroup (GCIG). Methods and Materials: A survey was developed and distributed to the members of the GCIG focusing on details of radiotherapy practice. Different scenarios were queried including advanced cervical cancer, postoperative patients, and para-aortic-positive lymph node cases. Items focused on indications for radiation therapy, radiation fields, dose, use of chemotherapy, brachytherapy and others. The cooperative groups from North America were compared with the other groups to evaluate potential differences in radiotherapy doses. Results: A total of 39 surveys were returned from 13 different cooperative groups. For the treatment of advanced cervical cancer, external beam pelvic doses and total doses to point A were 47 + 3.5 Gy (mean + SD) and 79.1 + 7.9 Gy, respectively. Point A doses were not different between the North American cooperative groups compared with the others (p = 0.103). All groups used concomitant chemotherapy, with 30 of 36 respondents using weekly cisplatin. Of 33 respondents, 31 intervened for a low hemoglobin level. For a para-aortic field, the upper border was most commonly (15 of 24) at the T12-L1 interspace. Maintenance chemotherapy (after radiotherapy) was not performed by 68% of respondents. For vaginal brachytherapy after hysterectomy, 23 groups performed HDR brachytherapy and four groups used LDR brachytherapy. In the use of brachytherapy, there was no uniformity in dose prescription. Conclusions: Radiotherapy practices among member groups of the GCIG are similar in terms of both doses and use of chemotherapy.

Original languageEnglish
Pages (from-to)485-490
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume68
Issue number2
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

Fingerprint

Brachytherapy
Uterine Cervical Neoplasms
radiation therapy
Radiotherapy
cancer
dosage
chemotherapy
Neoplasms
Drug Therapy
Maintenance Chemotherapy
North America
Hysterectomy
Cisplatin
Prescriptions
Large Deployable Reflector
Hemoglobins
Lymph Nodes
Surveys and Questionnaires
Radiation
lymphatic system

Keywords

  • Cervix
  • Chemoradiation
  • Cooperative group

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Practice Patterns of Radiotherapy in Cervical Cancer Among Member Groups of the Gynecologic Cancer Intergroup (GCIG). / Gaffney, David K.; Du Bois, Andreas; Narayan, Kailash; Reed, Nick; Toita, Takafumi; Pignata, Sandro; Blake, Peter; Portelance, Lorraine; Sadoyze, Azmat; Pötter, Richard; Colombo, Alessandro; Randall, Marcus; Mirza, Mansoor R.; Trimble, Edward L.

In: International Journal of Radiation Oncology Biology Physics, Vol. 68, No. 2, 01.06.2007, p. 485-490.

Research output: Contribution to journalArticle

Gaffney, DK, Du Bois, A, Narayan, K, Reed, N, Toita, T, Pignata, S, Blake, P, Portelance, L, Sadoyze, A, Pötter, R, Colombo, A, Randall, M, Mirza, MR & Trimble, EL 2007, 'Practice Patterns of Radiotherapy in Cervical Cancer Among Member Groups of the Gynecologic Cancer Intergroup (GCIG)', International Journal of Radiation Oncology Biology Physics, vol. 68, no. 2, pp. 485-490. https://doi.org/10.1016/j.ijrobp.2006.12.013
Gaffney, David K. ; Du Bois, Andreas ; Narayan, Kailash ; Reed, Nick ; Toita, Takafumi ; Pignata, Sandro ; Blake, Peter ; Portelance, Lorraine ; Sadoyze, Azmat ; Pötter, Richard ; Colombo, Alessandro ; Randall, Marcus ; Mirza, Mansoor R. ; Trimble, Edward L. / Practice Patterns of Radiotherapy in Cervical Cancer Among Member Groups of the Gynecologic Cancer Intergroup (GCIG). In: International Journal of Radiation Oncology Biology Physics. 2007 ; Vol. 68, No. 2. pp. 485-490.
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abstract = "Purpose: The aim of this study was to describe radiotherapeutic practice of the treatment of cervical cancer in member groups of the Gynecologic Cancer Intergroup (GCIG). Methods and Materials: A survey was developed and distributed to the members of the GCIG focusing on details of radiotherapy practice. Different scenarios were queried including advanced cervical cancer, postoperative patients, and para-aortic-positive lymph node cases. Items focused on indications for radiation therapy, radiation fields, dose, use of chemotherapy, brachytherapy and others. The cooperative groups from North America were compared with the other groups to evaluate potential differences in radiotherapy doses. Results: A total of 39 surveys were returned from 13 different cooperative groups. For the treatment of advanced cervical cancer, external beam pelvic doses and total doses to point A were 47 + 3.5 Gy (mean + SD) and 79.1 + 7.9 Gy, respectively. Point A doses were not different between the North American cooperative groups compared with the others (p = 0.103). All groups used concomitant chemotherapy, with 30 of 36 respondents using weekly cisplatin. Of 33 respondents, 31 intervened for a low hemoglobin level. For a para-aortic field, the upper border was most commonly (15 of 24) at the T12-L1 interspace. Maintenance chemotherapy (after radiotherapy) was not performed by 68{\%} of respondents. For vaginal brachytherapy after hysterectomy, 23 groups performed HDR brachytherapy and four groups used LDR brachytherapy. In the use of brachytherapy, there was no uniformity in dose prescription. Conclusions: Radiotherapy practices among member groups of the GCIG are similar in terms of both doses and use of chemotherapy.",
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AU - Toita, Takafumi

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AU - Blake, Peter

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AU - Sadoyze, Azmat

AU - Pötter, Richard

AU - Colombo, Alessandro

AU - Randall, Marcus

AU - Mirza, Mansoor R.

AU - Trimble, Edward L.

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