Abstract
Family-based tests of association are now often used when trying to fine-map a disease susceptibility locus. Recently, several tests of linkage and association have been proposed that use nuclear families with multiple affected and unaffected sibs rather than just case-parent triads. In this paper we propose a test that generalizes these previous tests. Formulae are derived to calculate the power of the test for a randomly mating population. These power calculations are used to determine conditions under which it is advantageous to include unaffected sibs in the analysis.
Original language | English (US) |
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Pages (from-to) | 193-201 |
Number of pages | 9 |
Journal | Theoretical Population Biology |
Volume | 60 |
Issue number | 3 |
DOIs | |
State | Published - Jan 1 2001 |
Externally published | Yes |
Keywords
- Association
- Linkage disequilibrium
- Nuclear families
- TDT
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Ecology, Evolution, Behavior and Systematics