Power calculations for a general class of tests of linkage and association that use nuclear families with affected and unaffected sibs

Norman L. Kaplan, Eden R. Martin

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Family-based tests of association are now often used when trying to fine-map a disease susceptibility locus. Recently, several tests of linkage and association have been proposed that use nuclear families with multiple affected and unaffected sibs rather than just case-parent triads. In this paper we propose a test that generalizes these previous tests. Formulae are derived to calculate the power of the test for a randomly mating population. These power calculations are used to determine conditions under which it is advantageous to include unaffected sibs in the analysis.

Original languageEnglish (US)
Pages (from-to)193-201
Number of pages9
JournalTheoretical Population Biology
Volume60
Issue number3
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • Association
  • Linkage disequilibrium
  • Nuclear families
  • TDT

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Ecology, Evolution, Behavior and Systematics

Fingerprint Dive into the research topics of 'Power calculations for a general class of tests of linkage and association that use nuclear families with affected and unaffected sibs'. Together they form a unique fingerprint.

  • Cite this