Abstract
Family-based tests of association are now often used when trying to fine-map a disease susceptibility locus. Recently, several tests of linkage and association have been proposed that use nuclear families with multiple affected and unaffected sibs rather than just case-parent triads. In this paper we propose a test that generalizes these previous tests. Formulae are derived to calculate the power of the test for a randomly mating population. These power calculations are used to determine conditions under which it is advantageous to include unaffected sibs in the analysis.
| Original language | English |
|---|---|
| Pages (from-to) | 193-201 |
| Number of pages | 9 |
| Journal | Theoretical Population Biology |
| Volume | 60 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 1 2001 |
| Externally published | Yes |
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Keywords
- Association
- Linkage disequilibrium
- Nuclear families
- TDT
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Ecology, Evolution, Behavior and Systematics
Cite this
Power calculations for a general class of tests of linkage and association that use nuclear families with affected and unaffected sibs. / Kaplan, Norman L.; Martin, Eden R.
In: Theoretical Population Biology, Vol. 60, No. 3, 01.12.2001, p. 193-201.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Power calculations for a general class of tests of linkage and association that use nuclear families with affected and unaffected sibs
AU - Kaplan, Norman L.
AU - Martin, Eden R
PY - 2001/12/1
Y1 - 2001/12/1
N2 - Family-based tests of association are now often used when trying to fine-map a disease susceptibility locus. Recently, several tests of linkage and association have been proposed that use nuclear families with multiple affected and unaffected sibs rather than just case-parent triads. In this paper we propose a test that generalizes these previous tests. Formulae are derived to calculate the power of the test for a randomly mating population. These power calculations are used to determine conditions under which it is advantageous to include unaffected sibs in the analysis.
AB - Family-based tests of association are now often used when trying to fine-map a disease susceptibility locus. Recently, several tests of linkage and association have been proposed that use nuclear families with multiple affected and unaffected sibs rather than just case-parent triads. In this paper we propose a test that generalizes these previous tests. Formulae are derived to calculate the power of the test for a randomly mating population. These power calculations are used to determine conditions under which it is advantageous to include unaffected sibs in the analysis.
KW - Association
KW - Linkage disequilibrium
KW - Nuclear families
KW - TDT
UR - http://www.scopus.com/inward/record.url?scp=0035528924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035528924&partnerID=8YFLogxK
U2 - 10.1006/tpbi.2001.1541
DO - 10.1006/tpbi.2001.1541
M3 - Article
C2 - 11855953
AN - SCOPUS:0035528924
VL - 60
SP - 193
EP - 201
JO - Theoretical Population Biology
JF - Theoretical Population Biology
SN - 0040-5809
IS - 3
ER -