Power calculations for a general class of tests of linkage and association that use nuclear families with affected and unaffected sibs

Norman L. Kaplan, Eden R Martin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Family-based tests of association are now often used when trying to fine-map a disease susceptibility locus. Recently, several tests of linkage and association have been proposed that use nuclear families with multiple affected and unaffected sibs rather than just case-parent triads. In this paper we propose a test that generalizes these previous tests. Formulae are derived to calculate the power of the test for a randomly mating population. These power calculations are used to determine conditions under which it is advantageous to include unaffected sibs in the analysis.

Original languageEnglish
Pages (from-to)193-201
Number of pages9
JournalTheoretical Population Biology
Volume60
Issue number3
DOIs
StatePublished - Dec 1 2001
Externally publishedYes

Fingerprint

nuclear family
Disease Susceptibility
Nuclear Family
linkage (genetics)
Population
testing
disease resistance
Power (Psychology)
test
family
calculation
loci

Keywords

  • Association
  • Linkage disequilibrium
  • Nuclear families
  • TDT

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Ecology, Evolution, Behavior and Systematics

Cite this

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