Potential use of lasers for penetrating keratoplasty

K. P. Thompson, E. Barraquer, Jean-Marie A Parel, H. Loertscher, S. Pflugfelder, T. Roussel, S. Holland, K. Hanna

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Experimental corneal trephination has been achieved with the 193 nm argon fluoride excimer and 2.9 μm hydrogen fluoride and Er:YAG laser systems. Compared with metal blades and other lasers, the 193 nm excimer laser creates the best quality corneal excision, but has a relatively slow etch rate through the stroma, and its use requires toxic gas. The mid-infrared laser systems trephine the cornea in less than 10 seconds, but cause a 10 μm to 15 μm zone of adjacent stromal damage and create wounds that are approximately 2.5 times larger than wounds made by metal scalpels. The wavelengths and laser pulse duration influence the cutting characteristics of the laser. Optical delivery systems using an axicon lens, a rotating slit, and a computer controlled scanning optical system have been developed for penetrating keratoplasty. Selection of the optimal laser system for penetrating keratoplasty must await further experimental studies. Refinements of the laser cavity and delivery system are necessary before clinical studies can begin. A carefully controlled randomized clinical trial comparing laser trephination with conventional mechanical trephines will be necessary to determine the safety and efficacy of a laser trephination system.

Original languageEnglish
Pages (from-to)397-403
Number of pages7
JournalJournal of Cataract and Refractive Surgery
Volume15
Issue number4
StatePublished - Jan 1 1989

Fingerprint

Penetrating Keratoplasty
Lasers
Trephining
Optical Devices
Metals
Hydrofluoric Acid
Excimer Lasers
Poisons
Solid-State Lasers
Wounds and Injuries
Cornea
Lenses
Randomized Controlled Trials
Gases
Safety

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Thompson, K. P., Barraquer, E., Parel, J-M. A., Loertscher, H., Pflugfelder, S., Roussel, T., ... Hanna, K. (1989). Potential use of lasers for penetrating keratoplasty. Journal of Cataract and Refractive Surgery, 15(4), 397-403.

Potential use of lasers for penetrating keratoplasty. / Thompson, K. P.; Barraquer, E.; Parel, Jean-Marie A; Loertscher, H.; Pflugfelder, S.; Roussel, T.; Holland, S.; Hanna, K.

In: Journal of Cataract and Refractive Surgery, Vol. 15, No. 4, 01.01.1989, p. 397-403.

Research output: Contribution to journalArticle

Thompson, KP, Barraquer, E, Parel, J-MA, Loertscher, H, Pflugfelder, S, Roussel, T, Holland, S & Hanna, K 1989, 'Potential use of lasers for penetrating keratoplasty', Journal of Cataract and Refractive Surgery, vol. 15, no. 4, pp. 397-403.
Thompson KP, Barraquer E, Parel J-MA, Loertscher H, Pflugfelder S, Roussel T et al. Potential use of lasers for penetrating keratoplasty. Journal of Cataract and Refractive Surgery. 1989 Jan 1;15(4):397-403.
Thompson, K. P. ; Barraquer, E. ; Parel, Jean-Marie A ; Loertscher, H. ; Pflugfelder, S. ; Roussel, T. ; Holland, S. ; Hanna, K. / Potential use of lasers for penetrating keratoplasty. In: Journal of Cataract and Refractive Surgery. 1989 ; Vol. 15, No. 4. pp. 397-403.
@article{bc5ab49a2e324ac99f4a707e8fcea771,
title = "Potential use of lasers for penetrating keratoplasty",
abstract = "Experimental corneal trephination has been achieved with the 193 nm argon fluoride excimer and 2.9 μm hydrogen fluoride and Er:YAG laser systems. Compared with metal blades and other lasers, the 193 nm excimer laser creates the best quality corneal excision, but has a relatively slow etch rate through the stroma, and its use requires toxic gas. The mid-infrared laser systems trephine the cornea in less than 10 seconds, but cause a 10 μm to 15 μm zone of adjacent stromal damage and create wounds that are approximately 2.5 times larger than wounds made by metal scalpels. The wavelengths and laser pulse duration influence the cutting characteristics of the laser. Optical delivery systems using an axicon lens, a rotating slit, and a computer controlled scanning optical system have been developed for penetrating keratoplasty. Selection of the optimal laser system for penetrating keratoplasty must await further experimental studies. Refinements of the laser cavity and delivery system are necessary before clinical studies can begin. A carefully controlled randomized clinical trial comparing laser trephination with conventional mechanical trephines will be necessary to determine the safety and efficacy of a laser trephination system.",
author = "Thompson, {K. P.} and E. Barraquer and Parel, {Jean-Marie A} and H. Loertscher and S. Pflugfelder and T. Roussel and S. Holland and K. Hanna",
year = "1989",
month = "1",
day = "1",
language = "English",
volume = "15",
pages = "397--403",
journal = "Journal of Cataract and Refractive Surgery",
issn = "0886-3350",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Potential use of lasers for penetrating keratoplasty

AU - Thompson, K. P.

AU - Barraquer, E.

AU - Parel, Jean-Marie A

AU - Loertscher, H.

AU - Pflugfelder, S.

AU - Roussel, T.

AU - Holland, S.

AU - Hanna, K.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Experimental corneal trephination has been achieved with the 193 nm argon fluoride excimer and 2.9 μm hydrogen fluoride and Er:YAG laser systems. Compared with metal blades and other lasers, the 193 nm excimer laser creates the best quality corneal excision, but has a relatively slow etch rate through the stroma, and its use requires toxic gas. The mid-infrared laser systems trephine the cornea in less than 10 seconds, but cause a 10 μm to 15 μm zone of adjacent stromal damage and create wounds that are approximately 2.5 times larger than wounds made by metal scalpels. The wavelengths and laser pulse duration influence the cutting characteristics of the laser. Optical delivery systems using an axicon lens, a rotating slit, and a computer controlled scanning optical system have been developed for penetrating keratoplasty. Selection of the optimal laser system for penetrating keratoplasty must await further experimental studies. Refinements of the laser cavity and delivery system are necessary before clinical studies can begin. A carefully controlled randomized clinical trial comparing laser trephination with conventional mechanical trephines will be necessary to determine the safety and efficacy of a laser trephination system.

AB - Experimental corneal trephination has been achieved with the 193 nm argon fluoride excimer and 2.9 μm hydrogen fluoride and Er:YAG laser systems. Compared with metal blades and other lasers, the 193 nm excimer laser creates the best quality corneal excision, but has a relatively slow etch rate through the stroma, and its use requires toxic gas. The mid-infrared laser systems trephine the cornea in less than 10 seconds, but cause a 10 μm to 15 μm zone of adjacent stromal damage and create wounds that are approximately 2.5 times larger than wounds made by metal scalpels. The wavelengths and laser pulse duration influence the cutting characteristics of the laser. Optical delivery systems using an axicon lens, a rotating slit, and a computer controlled scanning optical system have been developed for penetrating keratoplasty. Selection of the optimal laser system for penetrating keratoplasty must await further experimental studies. Refinements of the laser cavity and delivery system are necessary before clinical studies can begin. A carefully controlled randomized clinical trial comparing laser trephination with conventional mechanical trephines will be necessary to determine the safety and efficacy of a laser trephination system.

UR - http://www.scopus.com/inward/record.url?scp=0024407342&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024407342&partnerID=8YFLogxK

M3 - Article

C2 - 2674411

AN - SCOPUS:0024407342

VL - 15

SP - 397

EP - 403

JO - Journal of Cataract and Refractive Surgery

JF - Journal of Cataract and Refractive Surgery

SN - 0886-3350

IS - 4

ER -