Abstract
The integral membrane glycoprotein presenilin-1 (PS1), in concert with β-secretase and beta amyloid precursor protein (βAPP), orchestrate cleavage of βAPP into amyloidogenic Aβ peptides.To gain further insight into PS1 function, we undertook a gene expression profiling study that interrogated the expression of 12 000 genes in the forebrain of PS1-hypomorphic mice that exhibit highly attenuated PS1 activity. Using stringent RNA screening, DNA array and Northern assay, we report significant down-regulation in the expression of βAPP and hypoxia inducible factor-1 alpha (HIF-1α), and a marked up-regulation in the expression of glial-specific markers that include S100β protein, glycerol phosphate dehydrogenase, and glial fibrillary acidic protein. These data suggest potential roles for PS1 in the cellular response to hypoxia and glial-specific gene expression.
Original language | English (US) |
---|---|
Pages (from-to) | 2025-2028 |
Number of pages | 4 |
Journal | Neuroreport |
Volume | 15 |
Issue number | 13 |
DOIs | |
State | Published - Sep 1 2004 |
Keywords
- Aβ peptides
- Alzheimer's disease
- Glial fibrillary acidic protein
- Gliosis
- Glycerol phosphate dehydrogenase
- Hypomorphic mice
- Hypoxia inducible factor 1 alpha
- S100β protein
ASJC Scopus subject areas
- Neuroscience(all)