Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression

Jian Guo Cui, Paul E. Fraser, Peter St. George-Hyslop, David Westaway, Walter J. Lukiw

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The integral membrane glycoprotein presenilin-1 (PS1), in concert with β-secretase and beta amyloid precursor protein (βAPP), orchestrate cleavage of βAPP into amyloidogenic Aβ peptides.To gain further insight into PS1 function, we undertook a gene expression profiling study that interrogated the expression of 12 000 genes in the forebrain of PS1-hypomorphic mice that exhibit highly attenuated PS1 activity. Using stringent RNA screening, DNA array and Northern assay, we report significant down-regulation in the expression of βAPP and hypoxia inducible factor-1 alpha (HIF-1α), and a marked up-regulation in the expression of glial-specific markers that include S100β protein, glycerol phosphate dehydrogenase, and glial fibrillary acidic protein. These data suggest potential roles for PS1 in the cellular response to hypoxia and glial-specific gene expression.

Original languageEnglish (US)
Pages (from-to)2025-2028
Number of pages4
JournalNeuroreport
Volume15
Issue number13
DOIs
StatePublished - Sep 1 2004

Keywords

  • Aβ peptides
  • Alzheimer's disease
  • Glial fibrillary acidic protein
  • Gliosis
  • Glycerol phosphate dehydrogenase
  • Hypomorphic mice
  • Hypoxia inducible factor 1 alpha
  • S100β protein

ASJC Scopus subject areas

  • Neuroscience(all)

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    Cui, J. G., Fraser, P. E., St. George-Hyslop, P., Westaway, D., & Lukiw, W. J. (2004). Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression. Neuroreport, 15(13), 2025-2028. https://doi.org/10.1097/00001756-200409150-00006