Potent reduction of basal acid output produced by meperidine

Jose Carlos Meeroff, Graciela Garcia Fernandez, David Gaon

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Meperidine is a potent narcotic related chemically and pharmacologically to morphine and atropine. To examine its gastric antisecretory activity a study designed to test the effect of meperidine on basal acid secretion was carried out: 100 mg of meperidine given intramuscularly reduced basal acid output (BAO) by 66.3% at 1 hr (P<0.001), 64.9% at 2 hr (P<0.001), and 44.9% at 3 hr (P=0.005). This degree of reduction of BAO by this dose of meperidine did not differ from that produced by 30 mg of propantheline intramuscularly. These results demonstrate that meperidine in standard classical doses is a potent inhibitor of BAO in man.

Original languageEnglish (US)
Pages (from-to)696-698
Number of pages3
JournalThe American Journal of Digestive Diseases
Issue number8
StatePublished - Aug 1978
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology


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