Potent reduction of basal acid output produced by meperidine

Jose Carlos Meeroff, Graciela Garcia Fernandez, David Gaon

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Meperidine is a potent narcotic related chemically and pharmacologically to morphine and atropine. To examine its gastric antisecretory activity a study designed to test the effect of meperidine on basal acid secretion was carried out: 100 mg of meperidine given intramuscularly reduced basal acid output (BAO) by 66.3% at 1 hr (P<0.001), 64.9% at 2 hr (P<0.001), and 44.9% at 3 hr (P=0.005). This degree of reduction of BAO by this dose of meperidine did not differ from that produced by 30 mg of propantheline intramuscularly. These results demonstrate that meperidine in standard classical doses is a potent inhibitor of BAO in man.

Original languageEnglish
Pages (from-to)696-698
Number of pages3
JournalThe American Journal of Digestive Diseases
Volume23
Issue number8
DOIs
StatePublished - Aug 1 1978

Fingerprint

Meperidine
Acids
Propantheline
Narcotics
Stomach

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Potent reduction of basal acid output produced by meperidine. / Meeroff, Jose Carlos; Fernandez, Graciela Garcia; Gaon, David.

In: The American Journal of Digestive Diseases, Vol. 23, No. 8, 01.08.1978, p. 696-698.

Research output: Contribution to journalArticle

Meeroff, Jose Carlos ; Fernandez, Graciela Garcia ; Gaon, David. / Potent reduction of basal acid output produced by meperidine. In: The American Journal of Digestive Diseases. 1978 ; Vol. 23, No. 8. pp. 696-698.
@article{66cb70e5c6ea477ca7769529412f70a3,
title = "Potent reduction of basal acid output produced by meperidine",
abstract = "Meperidine is a potent narcotic related chemically and pharmacologically to morphine and atropine. To examine its gastric antisecretory activity a study designed to test the effect of meperidine on basal acid secretion was carried out: 100 mg of meperidine given intramuscularly reduced basal acid output (BAO) by 66.3{\%} at 1 hr (P<0.001), 64.9{\%} at 2 hr (P<0.001), and 44.9{\%} at 3 hr (P=0.005). This degree of reduction of BAO by this dose of meperidine did not differ from that produced by 30 mg of propantheline intramuscularly. These results demonstrate that meperidine in standard classical doses is a potent inhibitor of BAO in man.",
author = "Meeroff, {Jose Carlos} and Fernandez, {Graciela Garcia} and David Gaon",
year = "1978",
month = "8",
day = "1",
doi = "10.1007/BF01072354",
language = "English",
volume = "23",
pages = "696--698",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Plenum Publishers",
number = "8",

}

TY - JOUR

T1 - Potent reduction of basal acid output produced by meperidine

AU - Meeroff, Jose Carlos

AU - Fernandez, Graciela Garcia

AU - Gaon, David

PY - 1978/8/1

Y1 - 1978/8/1

N2 - Meperidine is a potent narcotic related chemically and pharmacologically to morphine and atropine. To examine its gastric antisecretory activity a study designed to test the effect of meperidine on basal acid secretion was carried out: 100 mg of meperidine given intramuscularly reduced basal acid output (BAO) by 66.3% at 1 hr (P<0.001), 64.9% at 2 hr (P<0.001), and 44.9% at 3 hr (P=0.005). This degree of reduction of BAO by this dose of meperidine did not differ from that produced by 30 mg of propantheline intramuscularly. These results demonstrate that meperidine in standard classical doses is a potent inhibitor of BAO in man.

AB - Meperidine is a potent narcotic related chemically and pharmacologically to morphine and atropine. To examine its gastric antisecretory activity a study designed to test the effect of meperidine on basal acid secretion was carried out: 100 mg of meperidine given intramuscularly reduced basal acid output (BAO) by 66.3% at 1 hr (P<0.001), 64.9% at 2 hr (P<0.001), and 44.9% at 3 hr (P=0.005). This degree of reduction of BAO by this dose of meperidine did not differ from that produced by 30 mg of propantheline intramuscularly. These results demonstrate that meperidine in standard classical doses is a potent inhibitor of BAO in man.

UR - http://www.scopus.com/inward/record.url?scp=0017840894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017840894&partnerID=8YFLogxK

U2 - 10.1007/BF01072354

DO - 10.1007/BF01072354

M3 - Article

VL - 23

SP - 696

EP - 698

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 8

ER -