Potent inhibitory activity of [D-LEU6, DES-GLY-NH21Q]LHRH ethylamide on LH/hCG and prl testicular receptor levels in the rat

C. Auclair; P. A. Kelly; D. H. Coy; A. V. Schally; F. Labrie; C. Auclair; P. A. Kelly; D. H. Coy; A. V. Schally; F. Labrie

doi:10.1210/endo-101-6-1890

Potent inhibitory activity of [D-LEU⁶, DES-GLY-NH₂1Q]LHRH ethylamide on LH/hCG and prl testicular receptor levels in the rat

C. Auclair, P. A. Kelly, D. H. Coy, A. V. Schally, F. Labrie, C. Auclair, P. A. Kelly, D. H. Coy, A. V. Schally, F. Labrie

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Injection of male rats with 40-200 ng of [D-Leu ⁶, des-Gly-NH ₂ ¹⁰]LHRH ethylamide for 7 days caused a maximal 80% reduction of testicular LH/hCG receptor level with 1 injection per day being as efficient as 3 daily injections. A similar inhibitory effect was observed on testicular PRL receptors. Testis and seminal vesicle weight as well as plasma testosterone levels were also significantly reduced by this treatment. These data indicate that a LHRH agonist, when given at a relatively low dose, is capable of reducing testicular LH/hCG and PRL receptor levels as well as testicular function, the effect being probably mediated by increased endogenous gonadotropin secretion.

Original language	English (US)
Pages (from-to)	1890-1893
Number of pages	4
Journal	Endocrinology
Volume	101
Issue number	6
DOIs	https://doi.org/10.1210/endo-101-6-1890
State	Published - Dec 1977
Externally published	Yes

ASJC Scopus subject areas

Endocrinology

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Potent inhibitory activity of [D-LEU⁶, DES-GLY-NH₂1Q]LHRH ethylamide on LH/hCG and prl testicular receptor levels in the rat. / Auclair, C.; Kelly, P. A.; Coy, D. H.; Schally, A. V.; Labrie, F.; Auclair, C.; Kelly, P. A.; Coy, D. H.; Schally, A. V.; Labrie, F.

In: Endocrinology, Vol. 101, No. 6, 12.1977, p. 1890-1893.

Research output: Contribution to journal › Article › peer-review

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title = "Potent inhibitory activity of [D-LEU6, DES-GLY-NH21Q]LHRH ethylamide on LH/hCG and prl testicular receptor levels in the rat",

abstract = "Injection of male rats with 40-200 ng of [D-Leu 6, des-Gly-NH 2 10]LHRH ethylamide for 7 days caused a maximal 80% reduction of testicular LH/hCG receptor level with 1 injection per day being as efficient as 3 daily injections. A similar inhibitory effect was observed on testicular PRL receptors. Testis and seminal vesicle weight as well as plasma testosterone levels were also significantly reduced by this treatment. These data indicate that a LHRH agonist, when given at a relatively low dose, is capable of reducing testicular LH/hCG and PRL receptor levels as well as testicular function, the effect being probably mediated by increased endogenous gonadotropin secretion.",

author = "C. Auclair and Kelly, {P. A.} and Coy, {D. H.} and Schally, {A. V.} and F. Labrie and C. Auclair and Kelly, {P. A.} and Coy, {D. H.} and Schally, {A. V.} and F. Labrie",

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doi = "10.1210/endo-101-6-1890",

language = "English (US)",

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T1 - Potent inhibitory activity of [D-LEU6, DES-GLY-NH21Q]LHRH ethylamide on LH/hCG and prl testicular receptor levels in the rat

AU - Auclair, C.

AU - Kelly, P. A.

AU - Coy, D. H.

AU - Schally, A. V.

AU - Labrie, F.

AU - Auclair, C.

AU - Kelly, P. A.

AU - Coy, D. H.

AU - Schally, A. V.

AU - Labrie, F.

PY - 1977/12

Y1 - 1977/12

N2 - Injection of male rats with 40-200 ng of [D-Leu 6, des-Gly-NH 2 10]LHRH ethylamide for 7 days caused a maximal 80% reduction of testicular LH/hCG receptor level with 1 injection per day being as efficient as 3 daily injections. A similar inhibitory effect was observed on testicular PRL receptors. Testis and seminal vesicle weight as well as plasma testosterone levels were also significantly reduced by this treatment. These data indicate that a LHRH agonist, when given at a relatively low dose, is capable of reducing testicular LH/hCG and PRL receptor levels as well as testicular function, the effect being probably mediated by increased endogenous gonadotropin secretion.

AB - Injection of male rats with 40-200 ng of [D-Leu 6, des-Gly-NH 2 10]LHRH ethylamide for 7 days caused a maximal 80% reduction of testicular LH/hCG receptor level with 1 injection per day being as efficient as 3 daily injections. A similar inhibitory effect was observed on testicular PRL receptors. Testis and seminal vesicle weight as well as plasma testosterone levels were also significantly reduced by this treatment. These data indicate that a LHRH agonist, when given at a relatively low dose, is capable of reducing testicular LH/hCG and PRL receptor levels as well as testicular function, the effect being probably mediated by increased endogenous gonadotropin secretion.

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