Potassium in hypertension and cardiovascular disease

Hector Castro, Leopoldo Raij

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The increased prevalence of hypertension and cardiovascular disease in industrialized societies undoubtedly is associated with the modern high-sodium/low-potassium diet. Extensive experimental and clinical data strongly link potassium intake to cardiovascular outcome. Most studies suggest that the sodium-to-potassium intake ratio is a better predictor of cardiovascular outcome than either nutrient individually. A high-sodium/low-potassium environment results in significant abnormalities in central hemodynamics, leading to potential target organ damage. Altered renal sodium handling, impaired endothelium-dependent vasodilatation, and increased oxidative stress are important mediators of this effect. It remains of paramount importance to reinforce consumption of a low-sodium/high-potassium diet as a critical strategy for prevention and treatment of hypertension and cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)277-289
Number of pages13
JournalSeminars in Nephrology
Issue number3
StatePublished - May 2013
Externally publishedYes


  • Dietary sodium/potassium
  • Endothelium
  • Hypertension
  • Nitric oxide
  • Oxidative stress
  • Pulse pressure
  • Pulse wave velocity
  • Stroke

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Potassium in hypertension and cardiovascular disease'. Together they form a unique fingerprint.

Cite this