Postsynaptic filopodia in muscle cells interact with innervating motoneuron axons

Sarah Ritzenthaler, Emiko Suzuki, Akira Chiba

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Precise synaptogenesis is crucial to brain development, and depends on the ability of specific partner cells to locate and communicate with one another. Dynamic properties of axonal filopodia during synaptic targeting are well documented, but the cytomorphological dynamics of postsynaptic cells have received less attention. In Drosophila embryos, muscle cells bear numerous postsynaptic filopodia ('myopodia') during motoneuron targeting. Here we show that myopodia are actin-filled microprocesses, which progressively clustered at the site of motoneuron innervation while intermingling with presynaptic filopodia. In prospero mutants, which have severe delays in axon outgrowth from the CNS, myopodia were present initially but clustering behavior was not observed, demonstrating that clustering depends on innervating axons. Thus, postsynaptic filopodia are capable of intimate interaction with innervating presynaptic axons. We propose that, by contributing to direct long-distance cellular communication, they are dynamically involved in synaptic matchmaking.

Original languageEnglish
Pages (from-to)1012-1017
Number of pages6
JournalNature Neuroscience
Volume3
Issue number10
DOIs
StatePublished - Oct 1 2000
Externally publishedYes

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Pseudopodia
Motor Neurons
Muscle Cells
Axons
Cluster Analysis
Aptitude
Drosophila
Actins
Embryonic Structures
Communication
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Postsynaptic filopodia in muscle cells interact with innervating motoneuron axons. / Ritzenthaler, Sarah; Suzuki, Emiko; Chiba, Akira.

In: Nature Neuroscience, Vol. 3, No. 10, 01.10.2000, p. 1012-1017.

Research output: Contribution to journalArticle

Ritzenthaler, Sarah ; Suzuki, Emiko ; Chiba, Akira. / Postsynaptic filopodia in muscle cells interact with innervating motoneuron axons. In: Nature Neuroscience. 2000 ; Vol. 3, No. 10. pp. 1012-1017.
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