Postradiation multicentric osteosarcoma

Christopher Tillotson, Andrew Rosenberg, Mark Gebhardt, Daniel I. Rosenthal

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The oncogenic effects of radiation are well-established. Osteosarcomas and fibrosarcomas are the two most common histologic types of secondary sarcoma. In this article a case of postradiation osteosarcoma is presented in which four discrete foci of sarcomatous transformation have occurred in the tibia and fibula after irradiation for a rhabdomyosarcoma of the calf 8 years earlier. A review of the literature reveals no similar case. Although synchronous, multifocal osteosarcoma without prior radiation has been described, this case differs in clinical, radiographic, and pathologic features; it best fits the description of postradiation multicentric osteosarcoma.

Original languageEnglish (US)
Pages (from-to)67-71
Number of pages5
Issue number1
StatePublished - Jul 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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