Postpsychotic depression and negative symptoms: An investigation of syndromal overlap

S. G. Siris, F. Adan, M. Cohen, J. Mandeli, A. Aronson, E. Casey

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


The authors studied 46 patients with the operationally defined syndrome of postpsychotic depression following episodes of schizophrenia or schizoaffective disorder. Half of these patients were also found to satisfy criteria for negative symptoms. The patients with negative symptoms were rated as more severely ill on global measures, but there was only limited evidence that they were more depressed. Nevertheless, in a randomized double-blind trial of imipramine versus placebo as an adjunct to the fluphenazine decanoate and benztropine regimens of the patients with negative symptoms, the patients who received imipramine seemed to show more improvement.

Original languageEnglish (US)
Pages (from-to)1532-1537
Number of pages6
JournalAmerican Journal of Psychiatry
Issue number12
StatePublished - 1988

ASJC Scopus subject areas

  • Psychiatry and Mental health

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