Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles

Alexandre C. Ferreira, Arley A. Peter, Armando J Mendez, Joaquin J Jimenez, Lucia M. Mauro, Julio A. Chirinos, Reyan Ghany, Salim Virani, Santiago Garcia, Lawrence L. Horstman, Joshua Purow, Wenche Jy, Yeon Ahn, Eduardo De Marchena

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Background - This study evaluated a possible relationship between levels of endothelial microparticles (EMPs), known to be a sensitive indicator of endothelial disturbance, and changes in postprandial lipid levels in healthy volunteers after a low- or high-fat meal. Methods and Results - Eighteen healthy subjects without known cardiovascular risk factors were evaluated. Lipid and EMP levels were measured before and 1 and 3 hours after a single low- or high-fat isocaloric meal. The low-fat meal had no significant postprandial effect on EMPs or lipids compared with fasting levels. In contrast, a single high-fat meal significantly increased EMP levels after 1 and 3 hours, from 389±54 (thousands per milliliter) when fasting to 541±139 (P=0.0002) and 677±159 (P<0.0001), respectively, and correlated with a postprandial elevation in serum triglycerides. Conclusions - A single high-fat meal led to a significant elevation of plasma EMP levels in healthy, normolipidemic subjects and correlated with a postprandial elevation of serum triglycerides. EMPs may be an indirect marker of endothelial dysfunction or injury induced by postprandial triglyceride-rich lipoproteins.

Original languageEnglish
Pages (from-to)3599-3603
Number of pages5
JournalCirculation
Volume110
Issue number23
DOIs
StatePublished - Dec 7 2004

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Hypertriglyceridemia
Endothelial Cells
Fats
Meals
Healthy Volunteers
Triglycerides
Lipids
Fasting
Serum
Lipoproteins
Wounds and Injuries

Keywords

  • Endothelium
  • Hypertriglyceridemia
  • Microparticles

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles. / Ferreira, Alexandre C.; Peter, Arley A.; Mendez, Armando J; Jimenez, Joaquin J; Mauro, Lucia M.; Chirinos, Julio A.; Ghany, Reyan; Virani, Salim; Garcia, Santiago; Horstman, Lawrence L.; Purow, Joshua; Jy, Wenche; Ahn, Yeon; De Marchena, Eduardo.

In: Circulation, Vol. 110, No. 23, 07.12.2004, p. 3599-3603.

Research output: Contribution to journalArticle

Ferreira, AC, Peter, AA, Mendez, AJ, Jimenez, JJ, Mauro, LM, Chirinos, JA, Ghany, R, Virani, S, Garcia, S, Horstman, LL, Purow, J, Jy, W, Ahn, Y & De Marchena, E 2004, 'Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles', Circulation, vol. 110, no. 23, pp. 3599-3603. https://doi.org/10.1161/01.CIR.0000148820.55611.6B
Ferreira, Alexandre C. ; Peter, Arley A. ; Mendez, Armando J ; Jimenez, Joaquin J ; Mauro, Lucia M. ; Chirinos, Julio A. ; Ghany, Reyan ; Virani, Salim ; Garcia, Santiago ; Horstman, Lawrence L. ; Purow, Joshua ; Jy, Wenche ; Ahn, Yeon ; De Marchena, Eduardo. / Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles. In: Circulation. 2004 ; Vol. 110, No. 23. pp. 3599-3603.
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