Postoperative middle cerebral artery peak systolic velocity changes confirm physiological principles of the sequential laser technique for twin-twin transfusion syndrome

Bhuvan Pathak, Ruben Quintero, Eftichia Kontopoulos, Samer Assaf, David Miller, Ramen H. Chmait

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: Treatment of the twin-twin transfusion syndrome (TTTS) via sequential selective laser photocoagulation of communicating vessels (SQLPCV) mandates ablation of donor-to-recipient arteriovenous anastomoses first. It is hypothesized that SQLPCV facilitates intraoperative transfusion to the donor, thereby minimizing donor hypovolemia and anemia. We sought to determine if postoperative changes in fetal middle cerebral artery-peak systolic velocities (MCA-PSV) support this hypothesis. Materials and Methods: Patients undergoing preferential SQLPCV for TTTS had MCA-PSV measured 1 day before surgery and on postoperative day 1 (POD-1). Fetal anemia was defined as an MCA-PSV ≥1.5 multiples of the median (MoM). Exclusions included: POD-1 demise, missing MCA-PSV data, or gestational age <18 weeks. Results: Study criteria were met by 139 patients. Mean MCA-PSV in recipients increased from 0.97 to 1.15 MoM postoperatively (p < 0.0001). Donor mean MCA-PSV remained stable at 1.00 MoM preoperatively and 0.98 MoM postoperatively (p = 0.272). Nine fetuses, 6 donors and 3 recipients, had preoperative anemia; SQLPCV was not attempted in the 3 anemic recipients. Postoperatively, the proportion of donors with anemia remained stable (increase 3.6%, p = 0.419), and the proportion of recipients with anemia increased (increase 12.2%, p = 0.009). Discussion: Our findings confirm the presumed physiological basis for the SQLPCV treatment of TTTS.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalFetal Diagnosis and Therapy
Volume28
Issue number3
DOIs
StatePublished - Oct 1 2010

Fingerprint

Fetofetal Transfusion
Middle Cerebral Artery
Light Coagulation
Lasers
Tissue Donors
Anemia
Arteriovenous Anastomosis
Hypovolemia
Ambulatory Surgical Procedures
Gestational Age
Fetus
Therapeutics

Keywords

  • Fetal anemia
  • Middle cerebral artery Doppler
  • Operative fetoscopy
  • Sequential laser surgery
  • Twin-twin transfusion syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging

Cite this

Postoperative middle cerebral artery peak systolic velocity changes confirm physiological principles of the sequential laser technique for twin-twin transfusion syndrome. / Pathak, Bhuvan; Quintero, Ruben; Kontopoulos, Eftichia; Assaf, Samer; Miller, David; Chmait, Ramen H.

In: Fetal Diagnosis and Therapy, Vol. 28, No. 3, 01.10.2010, p. 140-144.

Research output: Contribution to journalArticle

Pathak, Bhuvan ; Quintero, Ruben ; Kontopoulos, Eftichia ; Assaf, Samer ; Miller, David ; Chmait, Ramen H. / Postoperative middle cerebral artery peak systolic velocity changes confirm physiological principles of the sequential laser technique for twin-twin transfusion syndrome. In: Fetal Diagnosis and Therapy. 2010 ; Vol. 28, No. 3. pp. 140-144.
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