Postexercise phosphocreatine resynthesis is slowed in multiple sclerosis

Jane A. Kent‐Braun, Khema R. Sharma, Robert G. Miller, Michael W. Weiner

Research output: Contribution to journalArticlepeer-review

102 Scopus citations


To determine whether skeletal muscle oxidative metabolism is impaired in multiple sclerosis (MS), phosphorus magnetic resonance spectroscopy was used to measure the rate of intramuscular phosphocreatine (PCr) resynthesis following exercise in MS and controls. Thirteen MS patients underwent intermittent isometric tetanic contractions of the dorsiflexor muscles elicited by stimulation of the peroneal nerve. Eight healthy control subjects performed voluntary isometric exercise of the same muscles. During exercise, there were no differences between groups in the fall of either PCr or pH. However, the half-time (T 1/2 ) of PCr recovery following exercise was significantly longer in MS (2.3 ± 0.3 min) compared to controls (1.2 ± 0.1 min, P < 0.02). These data provide evidence of slowed PCr resynthesis following exercise in MS, which indicates impaired oxidative capacity in the skeletal muscle of this group. This finding suggests that intramuscular changes consistent with deconditioning may be important in the altered muscle function of persons with MS.

Original languageEnglish (US)
Pages (from-to)835-841
Number of pages7
JournalMuscle & Nerve
Issue number8
StatePublished - Aug 1994
Externally publishedYes


  • deconditioning
  • magnetic resonance spectroscopy
  • oxidative metabolism

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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