Posterior urethral valves

Steve J. Hodges, Bhavin Patel, Gordon McLorie, Anthony Atala

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

The most common cause of lower urinary tract obstruction in male infants is posterior urethral valves. Although the incidence has remained stable, the neonatal mortality for this disorder has improved due to early diagnosis and intensive neonatal care, thanks in part to the widespread use of prenatal ultrasound evaluations. In fact, the most common reason for the diagnosis of posterior urethral valves presently is the evaluation of infants for prenatal hydronephrosis. Since these children are often diagnosed early, the urethral obstruction can be alleviated rapidly through catheter insertion and eventual surgery, and their metabolic derangements can be normalized without delay, avoiding preventable infant mortality. Of the children that survive, however, early diagnosis has not had much effect on their long-term prognosis, as 30% still develop renal insufficiency before adolescence. A better understanding of the exact cause of the congenital obstruction of the male posterior urethra, prevention of postnatal bladder and renal injury, and the development of safe methods to treat urethral obstruction prenatally (and thereby avoiding the bladder and renal damage due to obstructive uropathy) are the goals for the care of children with posterior urethral valves[1].

Original languageEnglish
Pages (from-to)1119-1126
Number of pages8
JournalTheScientificWorldJournal
Volume9
DOIs
StatePublished - Oct 14 2009
Externally publishedYes

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Keywords

  • Hydronephrosis
  • Posterior urethral valves

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Hodges, S. J., Patel, B., McLorie, G., & Atala, A. (2009). Posterior urethral valves. TheScientificWorldJournal, 9, 1119-1126. https://doi.org/10.1100/tsw.2009.127