Posterior spinal fusion for scoliosis in Duchenne muscular dystrophy diminishes the rate of respiratory decline

Maria V. Velasco, Andrew Colin, David Zurakowski, Basil T. Darras, Frederic Shapiro

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

STUDY DESIGN. To assess the rate of decline in pulmonary function in Duchenne muscular dystrophy (DMD) before and after posterior spinal fusion for scoliosis. OBJECTIVE. To compare the rate of respiratory decline using percent normal forced vital capacity (%FVC) measurements before and after posterior spinal fusion. SUMMARY OF BACKGROUND DATA. Posterior spinal fusion for scoliosis is used widely in DMD, although the long-term pulmonary effects have not been well established. METHODS. Fifty-six patients were assessed. Percent forced vital capacity was the outcome parameter with data analysis using a mixed-model repeated-measures ANOVA and paired t tests. Group 1: Inclusion criteria were a diagnosis of DMD, 2 or more pulmonary function tests presurgery, and 2 or more postsurgery. Group 2: The rates of respiratory decline before and after spinal fusion for the whole study population were determined by within- subjects mixed-model regression analysis to account for the varying number of FVC studies between patients and unequal spacing between tests. RESULTS. Group 1: 20 patients. Mean length of time of respiratory value determination was 2.5 ± 1.0 years presurgery and 5.6 ± 2.8 years postsurgery. Mean rate of decline presurgery was 8.0% ± 4.1% per year, which decreased to 3.9% ± 1.9% per year postsurgery (paired t test = 4.58, P < 0.0001). Group 2: 56 patients. The respiratory value determinations ranged from 4 years presurgery to 8 years postsurgery. The rates of respiratory decline based on the whole study population were 4% per year presurgery, which decreased to 1.75% per year postsurgery (F-test comparison of slopes = 19.71, P < 0.0001). CONCLUSIONS. Posterior spinal fusion for scoliosis in DMD is associated with a significant decrease in the rate of respiratory decline postsurgery compared with presurgery rates.

Original languageEnglish
Pages (from-to)459-465
Number of pages7
JournalSpine
Volume32
Issue number4
DOIs
StatePublished - Feb 1 2007

Fingerprint

Spinal Fusion
Duchenne Muscular Dystrophy
Scoliosis
Respiratory Rate
Vital Capacity
Lung
Respiratory Function Tests
Population
Analysis of Variance
Regression Analysis

Keywords

  • Duchenne muscular dystrophy
  • Posterior spinal fusion
  • Respiratory function
  • Scoliosis

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Orthopedics and Sports Medicine

Cite this

Posterior spinal fusion for scoliosis in Duchenne muscular dystrophy diminishes the rate of respiratory decline. / Velasco, Maria V.; Colin, Andrew; Zurakowski, David; Darras, Basil T.; Shapiro, Frederic.

In: Spine, Vol. 32, No. 4, 01.02.2007, p. 459-465.

Research output: Contribution to journalArticle

Velasco, Maria V. ; Colin, Andrew ; Zurakowski, David ; Darras, Basil T. ; Shapiro, Frederic. / Posterior spinal fusion for scoliosis in Duchenne muscular dystrophy diminishes the rate of respiratory decline. In: Spine. 2007 ; Vol. 32, No. 4. pp. 459-465.
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abstract = "STUDY DESIGN. To assess the rate of decline in pulmonary function in Duchenne muscular dystrophy (DMD) before and after posterior spinal fusion for scoliosis. OBJECTIVE. To compare the rate of respiratory decline using percent normal forced vital capacity ({\%}FVC) measurements before and after posterior spinal fusion. SUMMARY OF BACKGROUND DATA. Posterior spinal fusion for scoliosis is used widely in DMD, although the long-term pulmonary effects have not been well established. METHODS. Fifty-six patients were assessed. Percent forced vital capacity was the outcome parameter with data analysis using a mixed-model repeated-measures ANOVA and paired t tests. Group 1: Inclusion criteria were a diagnosis of DMD, 2 or more pulmonary function tests presurgery, and 2 or more postsurgery. Group 2: The rates of respiratory decline before and after spinal fusion for the whole study population were determined by within- subjects mixed-model regression analysis to account for the varying number of FVC studies between patients and unequal spacing between tests. RESULTS. Group 1: 20 patients. Mean length of time of respiratory value determination was 2.5 ± 1.0 years presurgery and 5.6 ± 2.8 years postsurgery. Mean rate of decline presurgery was 8.0{\%} ± 4.1{\%} per year, which decreased to 3.9{\%} ± 1.9{\%} per year postsurgery (paired t test = 4.58, P < 0.0001). Group 2: 56 patients. The respiratory value determinations ranged from 4 years presurgery to 8 years postsurgery. The rates of respiratory decline based on the whole study population were 4{\%} per year presurgery, which decreased to 1.75{\%} per year postsurgery (F-test comparison of slopes = 19.71, P < 0.0001). CONCLUSIONS. Posterior spinal fusion for scoliosis in DMD is associated with a significant decrease in the rate of respiratory decline postsurgery compared with presurgery rates.",
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N2 - STUDY DESIGN. To assess the rate of decline in pulmonary function in Duchenne muscular dystrophy (DMD) before and after posterior spinal fusion for scoliosis. OBJECTIVE. To compare the rate of respiratory decline using percent normal forced vital capacity (%FVC) measurements before and after posterior spinal fusion. SUMMARY OF BACKGROUND DATA. Posterior spinal fusion for scoliosis is used widely in DMD, although the long-term pulmonary effects have not been well established. METHODS. Fifty-six patients were assessed. Percent forced vital capacity was the outcome parameter with data analysis using a mixed-model repeated-measures ANOVA and paired t tests. Group 1: Inclusion criteria were a diagnosis of DMD, 2 or more pulmonary function tests presurgery, and 2 or more postsurgery. Group 2: The rates of respiratory decline before and after spinal fusion for the whole study population were determined by within- subjects mixed-model regression analysis to account for the varying number of FVC studies between patients and unequal spacing between tests. RESULTS. Group 1: 20 patients. Mean length of time of respiratory value determination was 2.5 ± 1.0 years presurgery and 5.6 ± 2.8 years postsurgery. Mean rate of decline presurgery was 8.0% ± 4.1% per year, which decreased to 3.9% ± 1.9% per year postsurgery (paired t test = 4.58, P < 0.0001). Group 2: 56 patients. The respiratory value determinations ranged from 4 years presurgery to 8 years postsurgery. The rates of respiratory decline based on the whole study population were 4% per year presurgery, which decreased to 1.75% per year postsurgery (F-test comparison of slopes = 19.71, P < 0.0001). CONCLUSIONS. Posterior spinal fusion for scoliosis in DMD is associated with a significant decrease in the rate of respiratory decline postsurgery compared with presurgery rates.

AB - STUDY DESIGN. To assess the rate of decline in pulmonary function in Duchenne muscular dystrophy (DMD) before and after posterior spinal fusion for scoliosis. OBJECTIVE. To compare the rate of respiratory decline using percent normal forced vital capacity (%FVC) measurements before and after posterior spinal fusion. SUMMARY OF BACKGROUND DATA. Posterior spinal fusion for scoliosis is used widely in DMD, although the long-term pulmonary effects have not been well established. METHODS. Fifty-six patients were assessed. Percent forced vital capacity was the outcome parameter with data analysis using a mixed-model repeated-measures ANOVA and paired t tests. Group 1: Inclusion criteria were a diagnosis of DMD, 2 or more pulmonary function tests presurgery, and 2 or more postsurgery. Group 2: The rates of respiratory decline before and after spinal fusion for the whole study population were determined by within- subjects mixed-model regression analysis to account for the varying number of FVC studies between patients and unequal spacing between tests. RESULTS. Group 1: 20 patients. Mean length of time of respiratory value determination was 2.5 ± 1.0 years presurgery and 5.6 ± 2.8 years postsurgery. Mean rate of decline presurgery was 8.0% ± 4.1% per year, which decreased to 3.9% ± 1.9% per year postsurgery (paired t test = 4.58, P < 0.0001). Group 2: 56 patients. The respiratory value determinations ranged from 4 years presurgery to 8 years postsurgery. The rates of respiratory decline based on the whole study population were 4% per year presurgery, which decreased to 1.75% per year postsurgery (F-test comparison of slopes = 19.71, P < 0.0001). CONCLUSIONS. Posterior spinal fusion for scoliosis in DMD is associated with a significant decrease in the rate of respiratory decline postsurgery compared with presurgery rates.

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