Posterior fossa abnormalities in major depression: a controlled magnetic resonance imaging study

S. A. Shah, P. M. Doraiswamy, M. M. Husain, P. R. Escalona, C. Na, G. S. Figiel, L. J. Patterson, E. H. Ellinwood, W. M. McDonald, O. B. Boyko, C. B. Nemeroff, K. R.R. Krishnan

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

High-field magnetic resonance (MR) images were used to study posterior fossa morphology in 27 patients with major depression and 36 normal control subjects. Depressed patients demonstrated smaller brain stem and cerebellar vermis than controls. These differences were highly significant for the anterior cerebellar vermis and medulla. There was also a striking age-related decline in midbrain size in depressed patients as well as in controls. Our results are consistent with several lines of evidence implicating a role for the cerebellar vermis in affective disorders and, in addition, provide the first MR documentation of the differential effects of aging on posterior fossa morphology in normal subjects compared with patients with major depression.

Original languageEnglish (US)
Pages (from-to)474-479
Number of pages6
JournalActa Psychiatrica Scandinavica
Volume85
Issue number6
DOIs
StatePublished - Jun 1992

Keywords

  • affective disorder
  • aging
  • brain morphology
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Shah, S. A., Doraiswamy, P. M., Husain, M. M., Escalona, P. R., Na, C., Figiel, G. S., Patterson, L. J., Ellinwood, E. H., McDonald, W. M., Boyko, O. B., Nemeroff, C. B., & Krishnan, K. R. R. (1992). Posterior fossa abnormalities in major depression: a controlled magnetic resonance imaging study. Acta Psychiatrica Scandinavica, 85(6), 474-479. https://doi.org/10.1111/j.1600-0447.1992.tb03214.x