Posterior fixation keratoprostheses and mechanical biocompatibility

Determination of critical intraocular pressure causing aqueous humor leak and/or keratoprosthesis extrusion

Hassan Tahi, Bernard Duchesne, Jean-Marie A Parel, Izuru Nose, David B. Denham, Franck L. Villain, Emmanuel Lacombe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Purpose. The effect of increased intraocular pressure (IOP) in human cadaver eyes implanted with posterior fixation keratoprosthesis was evaluated. Methods. Experiments were carried out with six fresh pairs of human cadaver eyes. One eye of each pair was implanted with a PCL-5 keratoprosthesis (8.60 mm diameter with an optic of 5.60 nm diameter) and the contralateral eye was used as a control. The keratoprosthesis was inserted through a 6 mm diameter opening trephined in the cornea. The resistance of the implanted eye to pressure on "aqueous humor" leak and/or keratoprosthesis extrusion was tested by infusing water at a constant flow of 60 mmHg/second into the anterior chamber. IOP variations were recorded with a transducer connected to a computer. Results. IOP could be increased up to 1520 to 2324 mmHg before aqueous humor leaks occurred. Leaks were always located at the keratoprosthesis-cornea interface. No prosthesis extrusion was observed. Implanted eyes that did not leak aqueous and control eyes tore at the sclera. Conclusions. All posterior fixation keratoprostheses implanted eyes resisted more than 100 times the normal physiological intraocular pressure and on this standpoint is safe. Additional experiments were needed to assess the influence of suture fixation and wound healing in an animal model.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Pages147-151
Number of pages5
Volume2971
DOIs
StatePublished - 1997
EventOphthalmic Technologies VII - San Jose, CA, United States
Duration: Feb 8 1997Feb 8 1997

Other

OtherOphthalmic Technologies VII
CountryUnited States
CitySan Jose, CA
Period2/8/972/8/97

Fingerprint

intraocular pressure
critical pressure
Extrusion
Fixation
biocompatibility
Biocompatibility
Cornea
cornea
Wound Healing
Animal Model
Transducer
Experiment
Optics
Transducers
wound healing
Animals
animal models
Experiments
healing
Water

Keywords

  • Aqueous leakage
  • Cornea
  • Extrusion
  • Intraocular pressure
  • Keratoprosthesis
  • Posterior fixation

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Tahi, H., Duchesne, B., Parel, J-M. A., Nose, I., Denham, D. B., Villain, F. L., & Lacombe, E. (1997). Posterior fixation keratoprostheses and mechanical biocompatibility: Determination of critical intraocular pressure causing aqueous humor leak and/or keratoprosthesis extrusion. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2971, pp. 147-151) https://doi.org/10.1117/12.275109

Posterior fixation keratoprostheses and mechanical biocompatibility : Determination of critical intraocular pressure causing aqueous humor leak and/or keratoprosthesis extrusion. / Tahi, Hassan; Duchesne, Bernard; Parel, Jean-Marie A; Nose, Izuru; Denham, David B.; Villain, Franck L.; Lacombe, Emmanuel.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2971 1997. p. 147-151.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tahi, H, Duchesne, B, Parel, J-MA, Nose, I, Denham, DB, Villain, FL & Lacombe, E 1997, Posterior fixation keratoprostheses and mechanical biocompatibility: Determination of critical intraocular pressure causing aqueous humor leak and/or keratoprosthesis extrusion. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 2971, pp. 147-151, Ophthalmic Technologies VII, San Jose, CA, United States, 2/8/97. https://doi.org/10.1117/12.275109
Tahi H, Duchesne B, Parel J-MA, Nose I, Denham DB, Villain FL et al. Posterior fixation keratoprostheses and mechanical biocompatibility: Determination of critical intraocular pressure causing aqueous humor leak and/or keratoprosthesis extrusion. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2971. 1997. p. 147-151 https://doi.org/10.1117/12.275109
Tahi, Hassan ; Duchesne, Bernard ; Parel, Jean-Marie A ; Nose, Izuru ; Denham, David B. ; Villain, Franck L. ; Lacombe, Emmanuel. / Posterior fixation keratoprostheses and mechanical biocompatibility : Determination of critical intraocular pressure causing aqueous humor leak and/or keratoprosthesis extrusion. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2971 1997. pp. 147-151
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abstract = "Purpose. The effect of increased intraocular pressure (IOP) in human cadaver eyes implanted with posterior fixation keratoprosthesis was evaluated. Methods. Experiments were carried out with six fresh pairs of human cadaver eyes. One eye of each pair was implanted with a PCL-5 keratoprosthesis (8.60 mm diameter with an optic of 5.60 nm diameter) and the contralateral eye was used as a control. The keratoprosthesis was inserted through a 6 mm diameter opening trephined in the cornea. The resistance of the implanted eye to pressure on {"}aqueous humor{"} leak and/or keratoprosthesis extrusion was tested by infusing water at a constant flow of 60 mmHg/second into the anterior chamber. IOP variations were recorded with a transducer connected to a computer. Results. IOP could be increased up to 1520 to 2324 mmHg before aqueous humor leaks occurred. Leaks were always located at the keratoprosthesis-cornea interface. No prosthesis extrusion was observed. Implanted eyes that did not leak aqueous and control eyes tore at the sclera. Conclusions. All posterior fixation keratoprostheses implanted eyes resisted more than 100 times the normal physiological intraocular pressure and on this standpoint is safe. Additional experiments were needed to assess the influence of suture fixation and wound healing in an animal model.",
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