Post-transplant diabetes mellitus and HCV seropositive status after renal transplantation: Meta-analysis of clinical studies

Fabrizio Fabrizi, Paul Martin, Vivek Dixit, Suphamai Bunnapradist, Fasiha Kanwal, Gareth Dulai

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Abstract

Hepatitis C virus (HCV) infection has a detrimental role on patient and graft survival after renal transplantation (RT). Some studies have also implicated HCV in the development of post-transplant diabetes mellitus (PTDM). We conducted a systematic review of the published medical literature of the relationship between anti-HCV seropositive status and DM after RT. The risk of DM occurrence in anti-HCV-positive and -negative patients after RT was regarded as the most reliable outcome end-point. We used the random effects model of DerSimonian and Laird to generate a summary estimate of the Odds Ratio (OD) of new onset DM in HCV-positive and -negative patients after kidney transplantation. Ten studies involving 2502 unique RT recipients were identified. The incidence of PTDM after RT ranged between 7.9% and 50%. The summary estimate for adjusted OR was 3.97 with a 95% confidence interval (CI) of 1.83-8.61 (p-value for homogeneity <0.0473). Thus, pooling of study results demonstrated the presence of a significant link between anti-HCV seropositive status and DM after RT. This relationship provides one potential explanation for the adverse effects of HCV on patient and graft survival after RT.

Original languageEnglish (US)
Pages (from-to)2433-2440
Number of pages8
JournalAmerican Journal of Transplantation
Volume5
Issue number10
DOIs
StatePublished - Oct 1 2005

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Keywords

  • Diabetes mellitus
  • Hepatitis C virus (HCV)
  • Meta-analysis
  • Observational studies
  • Renal transplantation (RT)

ASJC Scopus subject areas

  • Immunology

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