Post-translational modifications of Runx1 regulate its activity in the cell

Lan Wang, Gang Huang, Xinyang Zhao, Megan A. Hatlen, Ly Vu, Fan Liu, Stephen D Nimer

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy.

Original languageEnglish
Pages (from-to)30-34
Number of pages5
JournalBlood Cells, Molecules, and Diseases
Volume43
Issue number1
DOIs
StatePublished - Jul 1 2009
Externally publishedYes

Fingerprint

Histone Deacetylases
Gene Fusion
Protein-Serine-Threonine Kinases
DNA Methylation
Post Translational Protein Processing
Lysine
Leukemia
Therapeutics
human PRMT2 protein
Cell Self Renewal
Lysine Acetyltransferases

Keywords

  • Acetylation
  • Acetyltransferases
  • Leukemia
  • Methylation
  • Methyltransferases
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Hematology
  • Cell Biology

Cite this

Post-translational modifications of Runx1 regulate its activity in the cell. / Wang, Lan; Huang, Gang; Zhao, Xinyang; Hatlen, Megan A.; Vu, Ly; Liu, Fan; Nimer, Stephen D.

In: Blood Cells, Molecules, and Diseases, Vol. 43, No. 1, 01.07.2009, p. 30-34.

Research output: Contribution to journalArticle

Wang, Lan ; Huang, Gang ; Zhao, Xinyang ; Hatlen, Megan A. ; Vu, Ly ; Liu, Fan ; Nimer, Stephen D. / Post-translational modifications of Runx1 regulate its activity in the cell. In: Blood Cells, Molecules, and Diseases. 2009 ; Vol. 43, No. 1. pp. 30-34.
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