Post-translational modifications of Runx1 regulate its activity in the cell

Lan Wang, Gang Huang, Xinyang Zhao, Megan A. Hatlen, Ly Vu, Fan Liu, Stephen D. Nimer

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy.

Original languageEnglish (US)
Pages (from-to)30-34
Number of pages5
JournalBlood Cells, Molecules, and Diseases
Volume43
Issue number1
DOIs
StatePublished - Jul 2009

Keywords

  • Acetylation
  • Acetyltransferases
  • Leukemia
  • Methylation
  • Methyltransferases
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Hematology
  • Cell Biology

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