Post-secretory fate of host defence components in mucus

Matthias A Salathe, Rosanna Forteza, Gregory E Conner

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

Airway mucus is a complex mixture of secretory products that provide a multifaceted defence against infection. Among many antimicrobial substances, mucus contains a peroxidase identical to milk lactoperoxidase (LPO) that is produced by goblet cells and submucosal glands. Airway secretions contain the substrates for LPO, namely thiocyanate and hydrogen peroxide, at concentrations sufficient for production of the biocidal compound hypothiocyanite, a fact confirmed by us in vitro. In vivo, inhibition of airway LPO in sheep significantly inhibits bacterial clearance, suggesting that the LPO system is a major contributor to host defences. Since secretory products including LPO are believed to be steadily removed by mucociliary clearance, their amount and availability on the surface is thought to be controlled solely by secretion. In contrast to this paradigm, new data suggest that LPO and other substances are retained at the ciliary border of the airway epithelium by binding to surface-associated hyaluronan, thereby providing an apical, fully active enzyme pool. Thus, hyaluronan, secreted from submucosal gland cells, plays a previously unrecognized pivotal role in mucosal host defence by retaining LPO and possibly other substances important for first line host defence at the apical surface 'ready for use' and protected from ciliary clearance.

Original languageEnglish
Title of host publicationNovartis Foundation Symposium
Pages20-37
Number of pages18
Volume248
StatePublished - Dec 1 2002

Publication series

NameNovartis Foundation Symposium
Volume248

ASJC Scopus subject areas

  • Medicine(all)

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    Salathe, M. A., Forteza, R., & Conner, G. E. (2002). Post-secretory fate of host defence components in mucus. In Novartis Foundation Symposium (Vol. 248, pp. 20-37). (Novartis Foundation Symposium; Vol. 248).