Post-irradiation Regression of Choroidal Melanomas as a Risk Factor for Death from Metastatic Disease

James J. Augsburger, John W. Gamel, Jerry A. Shields, Arnold M. Markoe, Luther W. Brady

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


To determine the prognostic value of the regression rate of choroidal melanomas after cobalt-60 plaque radiotherapy, the authors performed a multivariate analysis on 159 patients treated with a cobalt plaque during the interval from 1976 through 1980. Thirty-three of the 159 patients had died as of the survey date; 29 of metastatic melanoma and 4 of other causes. Multivariate Cox proportional hazards modeling identified a two-term regression incorporating maximal basal tumor diameter at treatment and tumor thickness at 12 months posttreatment as the best model (P<0.005 for both parameters) for predicting length of tumor-free survival. These results are consistent with the hypothesis that rapid regression of a choroidal melanoma after cobalt-60 plaque radiotherapy is an unfavorable prognostic sign for prolonged metastasis-free survival.

Original languageEnglish (US)
Pages (from-to)1173-1177
Number of pages5
Issue number9
StatePublished - Jan 1 1987
Externally publishedYes


  • Cox model
  • choroidal melanoma
  • cobalt-60 plaque radiotherapy
  • tumor regression

ASJC Scopus subject areas

  • Ophthalmology


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