Post-Burn Pruritus and Its Management—Current and New Avenues for Treatment

Emilie Fowler; Gil Yosipovitch

doi:10.1007/s40719-019-00164-8

Post-Burn Pruritus and Its Management—Current and New Avenues for Treatment

Emilie Fowler, Gil Yosipovitch

Dermatology & Cutaneous Surgery

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Purpose of Review: This article seeks to review the current literature on post-burn pruritus and its treatments, as well as to propose new treatments that may be of potential benefit for these patients. Recent Findings: Post-burn pruritus has been reported to affect as many as 93% of patients after a burn injury. Pruritus is extremely distressing to these patients, yet the current state of treatment, mostly antihistamines and emollients, is still widely ineffective in providing relief of itch. Summary: Therapies that are effective in treating pruritus and that may act as superior treatment options for patients suffering from post-burn pruritus include gabapentin and pregabalin, topical ketamine-lidocaine-amitriptyline, opioid medications, neurokinin-1 inhibitors, antidepressants, anti-cytokines, PAR-2 inhibitors, and botulinum toxin among others.

Original language	English (US)
Pages (from-to)	90-98
Number of pages	9
Journal	Current Trauma Reports
Volume	5
Issue number	2
DOIs	https://doi.org/10.1007/s40719-019-00164-8
State	Published - Jun 15 2019

Keywords

Burn injury
Burn scar
Itch
Post-burn itch
Post-burn pruritus
Pruritus

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine
Rehabilitation

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10.1007/s40719-019-00164-8

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title = "Post-Burn Pruritus and Its Management—Current and New Avenues for Treatment",

abstract = "Purpose of Review: This article seeks to review the current literature on post-burn pruritus and its treatments, as well as to propose new treatments that may be of potential benefit for these patients. Recent Findings: Post-burn pruritus has been reported to affect as many as 93% of patients after a burn injury. Pruritus is extremely distressing to these patients, yet the current state of treatment, mostly antihistamines and emollients, is still widely ineffective in providing relief of itch. Summary: Therapies that are effective in treating pruritus and that may act as superior treatment options for patients suffering from post-burn pruritus include gabapentin and pregabalin, topical ketamine-lidocaine-amitriptyline, opioid medications, neurokinin-1 inhibitors, antidepressants, anti-cytokines, PAR-2 inhibitors, and botulinum toxin among others.",

keywords = "Burn injury, Burn scar, Itch, Post-burn itch, Post-burn pruritus, Pruritus",

author = "Emilie Fowler and Gil Yosipovitch",

note = "Funding Information: Dr. Yosipovitch reports grants and personal fees from TREVI, grants and personal fees from Menlo, personal fees from Sienna, personal fees from Galderma, grants and personal fees from Pfizer, grants and personal fees from Sanofi/ Regeneron, personal fees from Novartis, personal fees from Opko, personal fees from Bayer, and grants from Sun Pharma, outside the submitted work. Dr. Fowler has nothing to disclose. Publisher Copyright: {\textcopyright} 2019, Springer Nature Switzerland AG.",

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doi = "10.1007/s40719-019-00164-8",

language = "English (US)",

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AU - Yosipovitch, Gil

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PY - 2019/6/15

Y1 - 2019/6/15

N2 - Purpose of Review: This article seeks to review the current literature on post-burn pruritus and its treatments, as well as to propose new treatments that may be of potential benefit for these patients. Recent Findings: Post-burn pruritus has been reported to affect as many as 93% of patients after a burn injury. Pruritus is extremely distressing to these patients, yet the current state of treatment, mostly antihistamines and emollients, is still widely ineffective in providing relief of itch. Summary: Therapies that are effective in treating pruritus and that may act as superior treatment options for patients suffering from post-burn pruritus include gabapentin and pregabalin, topical ketamine-lidocaine-amitriptyline, opioid medications, neurokinin-1 inhibitors, antidepressants, anti-cytokines, PAR-2 inhibitors, and botulinum toxin among others.

AB - Purpose of Review: This article seeks to review the current literature on post-burn pruritus and its treatments, as well as to propose new treatments that may be of potential benefit for these patients. Recent Findings: Post-burn pruritus has been reported to affect as many as 93% of patients after a burn injury. Pruritus is extremely distressing to these patients, yet the current state of treatment, mostly antihistamines and emollients, is still widely ineffective in providing relief of itch. Summary: Therapies that are effective in treating pruritus and that may act as superior treatment options for patients suffering from post-burn pruritus include gabapentin and pregabalin, topical ketamine-lidocaine-amitriptyline, opioid medications, neurokinin-1 inhibitors, antidepressants, anti-cytokines, PAR-2 inhibitors, and botulinum toxin among others.

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Post-Burn Pruritus and Its Management—Current and New Avenues for Treatment

Abstract

Keywords

ASJC Scopus subject areas

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