Abstract
Basophils are blood granulocytes and normally constitute <1% of blood peripheral leucocytes. Basophils share some morphological and functional similarities with mast cells, and basophils were once regarded as redundant and negligible circulating mast cells. However, recent studies reveal the indispensable roles of basophils in various diseases, including allergic and pruritic diseases. Basophils may be involved in itch through the mediation of a Th2 immune response, interaction with other cells in the skin and secretion of a wide variety of itch-related mediators, for example histamine, cytokines and chemokines (IL-4, IL-13, IL-31 and TSLP), proteases (cathepsin S), prostaglandins (PGE2 and PGD2), substance P and platelet-activating factor. Not only pruritic skin diseases (eg, atopic dermatitis, irritant contact dermatitis, chronic urticaria, prurigo, papulo-erythroderma of Ofuji, eosinophilic pustular folliculitis, scabies, tick bites and bullous pemphigoid) but also pruritic systemic diseases (eg, primary sclerosing cholangitis and polycythemia vera) may be affected by basophils.
| Original language | English (US) |
|---|---|
| Journal | Experimental Dermatology |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- mediator
- pruritic skin disease
- pruritic systemic disease
- pruritogen
- pruritus
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
Cite this
Possible roles of basophils in chronic itch. / Hashimoto, Takashi; Rosen, Jordan D.; Sanders, Kristen M.; Yosipovitch, Gil.
In: Experimental Dermatology, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Possible roles of basophils in chronic itch
AU - Hashimoto, Takashi
AU - Rosen, Jordan D.
AU - Sanders, Kristen M.
AU - Yosipovitch, Gil
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Basophils are blood granulocytes and normally constitute <1% of blood peripheral leucocytes. Basophils share some morphological and functional similarities with mast cells, and basophils were once regarded as redundant and negligible circulating mast cells. However, recent studies reveal the indispensable roles of basophils in various diseases, including allergic and pruritic diseases. Basophils may be involved in itch through the mediation of a Th2 immune response, interaction with other cells in the skin and secretion of a wide variety of itch-related mediators, for example histamine, cytokines and chemokines (IL-4, IL-13, IL-31 and TSLP), proteases (cathepsin S), prostaglandins (PGE2 and PGD2), substance P and platelet-activating factor. Not only pruritic skin diseases (eg, atopic dermatitis, irritant contact dermatitis, chronic urticaria, prurigo, papulo-erythroderma of Ofuji, eosinophilic pustular folliculitis, scabies, tick bites and bullous pemphigoid) but also pruritic systemic diseases (eg, primary sclerosing cholangitis and polycythemia vera) may be affected by basophils.
AB - Basophils are blood granulocytes and normally constitute <1% of blood peripheral leucocytes. Basophils share some morphological and functional similarities with mast cells, and basophils were once regarded as redundant and negligible circulating mast cells. However, recent studies reveal the indispensable roles of basophils in various diseases, including allergic and pruritic diseases. Basophils may be involved in itch through the mediation of a Th2 immune response, interaction with other cells in the skin and secretion of a wide variety of itch-related mediators, for example histamine, cytokines and chemokines (IL-4, IL-13, IL-31 and TSLP), proteases (cathepsin S), prostaglandins (PGE2 and PGD2), substance P and platelet-activating factor. Not only pruritic skin diseases (eg, atopic dermatitis, irritant contact dermatitis, chronic urticaria, prurigo, papulo-erythroderma of Ofuji, eosinophilic pustular folliculitis, scabies, tick bites and bullous pemphigoid) but also pruritic systemic diseases (eg, primary sclerosing cholangitis and polycythemia vera) may be affected by basophils.
KW - mediator
KW - pruritic skin disease
KW - pruritic systemic disease
KW - pruritogen
KW - pruritus
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UR - http://www.scopus.com/inward/citedby.url?scp=85052642947&partnerID=8YFLogxK
U2 - 10.1111/exd.13705
DO - 10.1111/exd.13705
M3 - Article
AN - SCOPUS:85052642947
JO - Experimental Dermatology
JF - Experimental Dermatology
SN - 0906-6705
ER -