Possible roles of basophils in chronic itch

Takashi Hashimoto, Jordan D. Rosen, Kristen M. Sanders, Gil Yosipovitch

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Basophils are blood granulocytes and normally constitute <1% of blood peripheral leucocytes. Basophils share some morphological and functional similarities with mast cells, and basophils were once regarded as redundant and negligible circulating mast cells. However, recent studies reveal the indispensable roles of basophils in various diseases, including allergic and pruritic diseases. Basophils may be involved in itch through the mediation of a Th2 immune response, interaction with other cells in the skin and secretion of a wide variety of itch-related mediators, for example histamine, cytokines and chemokines (IL-4, IL-13, IL-31 and TSLP), proteases (cathepsin S), prostaglandins (PGE2 and PGD2), substance P and platelet-activating factor. Not only pruritic skin diseases (eg, atopic dermatitis, irritant contact dermatitis, chronic urticaria, prurigo, papulo-erythroderma of Ofuji, eosinophilic pustular folliculitis, scabies, tick bites and bullous pemphigoid) but also pruritic systemic diseases (eg, primary sclerosing cholangitis and polycythemia vera) may be affected by basophils.

Original languageEnglish (US)
Pages (from-to)1373-1379
Number of pages7
JournalExperimental dermatology
Issue number12
StatePublished - Dec 1 2019


  • mediator
  • pruritic skin disease
  • pruritic systemic disease
  • pruritogen
  • pruritus

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology


Dive into the research topics of 'Possible roles of basophils in chronic itch'. Together they form a unique fingerprint.

Cite this