Possible Mechanism for Late Gestational Development of the Antioxidant Enzymes in the Fetal Rat Lung

Lee Frank, Lalitha T. Price, Philip L. Whitney

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

We hypothesized that a possible mechanism to explain the significant increases that occur in the pulmonary antioxidant enzyme (AOE) system late in gestation might be an endogenous increase in the normal reactive O2 substrates for these enzymes. We found that lung O2 free radical formation increased ~ 175% between fetal day 18 and birth (p < 0.01). We also found that late fetal rat lung mitochondrial and microsomal rates of AOE substrate (H2O2) generation increased markedly, and there was also significantly increased lung lipid peroxidation products with increasing gestational age. These definite elevations in reactive O2 species production in parallel with the time course of maturational elevations in the pulmonary AOE system, suggest that increasing enzyme substrate concentrations could be a primary controlling mechanism for increasing lung AOE gene expression in preparation for birth of the newborn.

Original languageEnglish (US)
Pages (from-to)116-127
Number of pages12
JournalNeonatology
Volume70
Issue number2
DOIs
StatePublished - Jan 1 1996

Keywords

  • Antioxidant enzymes
  • Fetal rat lung
  • Late gestational period
  • Lipid peroxidation
  • Lung development/maturation
  • O free radicals/reactive O species

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Possible Mechanism for Late Gestational Development of the Antioxidant Enzymes in the Fetal Rat Lung'. Together they form a unique fingerprint.

Cite this