Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac

S. Kodoth, S. Bakshi, P. Scimeca, K. Black, S. Pahwa

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The use of protease Inhibitors (PI) has been associated with many adverse effects including increased tendency to bleed, which is particularly problematic in individuals with congenital coagulation disorders. We report the occurrence of spontaneous intracranial bleeding in an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A who was receiving amprenavir (APV). The bleeding resolved on discontinuation of APV. This case report highlights a need for awareness of increased bleeding as a potentially serious complication associated with the use of all currently licensed PIs in individuals with hemophilia.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalAIDS patient care and STDs
Issue number7
StatePublished - Jul 30 2001
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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