Possible effects of antioxidant status on increased platelet aggregation in childhood iron-deficiency anemia

Demet Tekin, Sema Yavuzer, Mustafa Tekin, Nejat Akar, Sükrü Cin

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Background: Alterations in platelet function and antioxidant status in children with iron-deficiency anemia (IDA) have been reported previously. The present study was performed to better understand possible interactions between these two systems. Methods: Erythrocyte superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activity and platelet function were evaluated in 15 children (aged 1 1/2-15 years) with IDA. The antioxidant enzyme activity was determined spectrophotometrically. Platelet aggregation and secretion studies were performed using impedance and bioluminescence methods, respectively. Ten age-matched healthy children were included as a control group. Results: There were no differences in SOD and CAT activities between patients and controls. However, GSH-Px activity was significantly lower in the iron-deficient children. Platelet aggregation responses to collagen and ADP were also significantly higher in iron-deficient children than in controls. Conclusions: Decreased antioxidant defense in IDA may cause increased oxidant stress, which, in turn, may result in a tendency towards platelet aggregation.

Original languageEnglish (US)
Pages (from-to)74-77
Number of pages4
JournalPediatrics International
Issue number1
StatePublished - 2001
Externally publishedYes


  • Antioxidant enzymes
  • Children
  • Iron-deficiency anemia
  • Platelet functions

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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