Positive inotropic effects of NO donors in isolated guinea-pig and human cardiomyocytes independent of NO species and cyclic nucleotides

John W. McManus, Lambert A.B. Meñez, Kathleen N. Kesner-Reyes, Sheila G. Vergara, M. C. Ablan

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Coral reef fisheries support tens of millions of people, mostly in developing countries. Fishing on reefs can be classified into three stages: manageable, ecosystem-overfished, and Malthusian-overfished. Fishing with blasting devices and poisons is often associated with the third stage. Reductions in herbivory caused by overfishing may enhance the likelihood of organic pollution causing a coral-algal phase shift following major disturbances. However, cage studies indicate that reduction in herbivory can lead to the proliferation of algae even in the absence of eutrophication. A major concern with the widespread coral bleaching associated with the 1997-1998 El Nino event is the likelihood that reefs already stressed by overfishing and organic pollution may not return to coral dominance after severe bleaching. Clues to levels of fishing and to the potential to recover from disturbances include changes in the de-vegetated 'haloes' around coral stands on reef flats and the differing spectral signatures of live coral, recently dead coral, and coral covered with red encrusting, green filamentous, or brown frondose algae. These clues may facilitate broad area assessments of shallow reef areas via aircraft, space shuttles, or satellites. (C) 2000 International Council for the Exploration of the Sea.

Original languageEnglish (US)
Pages (from-to)430-439
Number of pages10
JournalCardiovascular Research
Volume48
Issue number3
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Contractile function
  • Myocytes
  • Nitric oxide

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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