TY - JOUR
T1 - Positive and negative psychotropic effects of lamotrigine in patients with epilepsy and mental retardation
AU - Ettinger, Alan B.
AU - Weisbrot, Deborah M.
AU - Saracco, Jennifer
AU - Dhoon, Aliasgar
AU - Kanner, Andres
AU - Devinsky, Orrin
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998/8
Y1 - 1998/8
N2 - Purpose: To describe significant positive or negative psychotropic effects of lamotrigine (LTG) observed in epilepsy patients with mental retardation (MR). Methods: Seven mentally retarded epilepsy patients, [5 with Lennox-Gastaut syndrome (LGS)] who experienced significant behavioral improvements or worsening after addition of LTG to their medication regimen were studied. Results: LTG produced behavioral improvements in 4 patients. Patient 1, a 14-year-old girl, had LTG added to valproate (VPA) and thioridazine, resulting in diminished lethargy, less hyperactivity, and more appropriate speech. In a 17-year-old boy (patient 2) LTG added to VPA, phenytoin (PHT), and gabapentin (GBP) lessened irritability and hyperactivity. In patient 3, a 41-year-old woman, LTG added to PHT, VPA, and carbamazepine (CBZ) diminished lethargy and enhanced her social interactions. In patient 4, a 27-year-old man, LTG mono-therapy diminished irritability and hyperactivity. Adverse behavioral effects were noted in 3 patients. In patient 5, a 43-year-old man, LTG added to PHT, phenobarbital (PB), lorazepam, sertraline, and thioridazine produced irritability, hyperactivity, and poor cooperation. In patient 6, a 29-year-old woman, LTG added to VPA produced frequent screaming, temper tantrums, increased rocking movements, and hyperactivity. In patient 7, a 29-year-old man, LTG added to VPA and PHT resulted in severe exacerbation of baseline behaviors, including self- injurious activity, temper tantrums, and failure to obey simple instructions. Conclusions: In some patients with epilepsy and MR, LTG has significant positive or negative effects on behavior.
AB - Purpose: To describe significant positive or negative psychotropic effects of lamotrigine (LTG) observed in epilepsy patients with mental retardation (MR). Methods: Seven mentally retarded epilepsy patients, [5 with Lennox-Gastaut syndrome (LGS)] who experienced significant behavioral improvements or worsening after addition of LTG to their medication regimen were studied. Results: LTG produced behavioral improvements in 4 patients. Patient 1, a 14-year-old girl, had LTG added to valproate (VPA) and thioridazine, resulting in diminished lethargy, less hyperactivity, and more appropriate speech. In a 17-year-old boy (patient 2) LTG added to VPA, phenytoin (PHT), and gabapentin (GBP) lessened irritability and hyperactivity. In patient 3, a 41-year-old woman, LTG added to PHT, VPA, and carbamazepine (CBZ) diminished lethargy and enhanced her social interactions. In patient 4, a 27-year-old man, LTG mono-therapy diminished irritability and hyperactivity. Adverse behavioral effects were noted in 3 patients. In patient 5, a 43-year-old man, LTG added to PHT, phenobarbital (PB), lorazepam, sertraline, and thioridazine produced irritability, hyperactivity, and poor cooperation. In patient 6, a 29-year-old woman, LTG added to VPA produced frequent screaming, temper tantrums, increased rocking movements, and hyperactivity. In patient 7, a 29-year-old man, LTG added to VPA and PHT resulted in severe exacerbation of baseline behaviors, including self- injurious activity, temper tantrums, and failure to obey simple instructions. Conclusions: In some patients with epilepsy and MR, LTG has significant positive or negative effects on behavior.
KW - Behavior
KW - Epilepsy
KW - Lamotrigine
KW - Mental retardation
KW - Psychotropic
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U2 - 10.1111/j.1528-1157.1998.tb01183.x
DO - 10.1111/j.1528-1157.1998.tb01183.x
M3 - Article
C2 - 9701379
AN - SCOPUS:0031868679
VL - 39
SP - 874
EP - 877
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 8
ER -