Population Genetic Structure of Anopheles arabiensis Mosquitoes in Ethiopia and Eritrea

S. R G Nyanjom, H. Chen, T. Gebre-Michael, E. Bekele, J. Shililu, J. Githure, John C Beier, Guiyun Yan

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

This study examined the population genetic structure of the major malaria vector, Anopheles arabiensis mosquitoes, in Ethiopia and Eritrea. Ethiopia and Eritrea have great geographical diversity, with high mountains, rugged plateaus, deep gorges, and rolling plains. The plateau is bisected diagonally by the Great Rift Valley into the Northwestern Highlands and the Southeastern Highlands. Five A. arabiensis populations from the Northwestern Highlands region and two populations from high-altitude sites in the Great Rift Valley were genotyped using six microsatellite markers to estimate the genetic diversity and population genetic structure of A. arabiensis. We found that A. arabiensis populations from the Northwestern Highlands and the Great Rift Valley region showed a similar level of genetic diversity. The genetic differentiation (FST) of the five mosquito populations within the Northwestern Highlands region was 0.038 (P < .001), while the two populations within the Great Rift Valley showed little genetic differentiation (FST = 0.007, P < .01). The degree of genetic differentiation between the Northwestern Highlands region and the Great Rift Valley region was small but statistically significant (FST = 0.017, P < .001). The population genetic structure of A. arabiensis in the study area did not follow the isolation-by-distance model (r2 = 0.014, P > .05). The low FST estimates for A. arabiensis populations in Ethiopia and Eritrea are consistent with the general population genetic structure of this species in East Africa based on other molecular markers.

Original languageEnglish
Pages (from-to)457-463
Number of pages7
JournalJournal of Heredity
Volume94
Issue number6
DOIs
StatePublished - Nov 1 2003
Externally publishedYes

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Eritrea
Anopheles arabiensis
Anopheles
Ethiopia
Genetic Structures
Population Genetics
Culicidae
population genetics
highlands
Population
valleys
genetic variation
plateaus
Eastern Africa
Microsatellite Repeats
Malaria
malaria
mountains
microsatellite repeats
genetic markers

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

Nyanjom, S. R. G., Chen, H., Gebre-Michael, T., Bekele, E., Shililu, J., Githure, J., ... Yan, G. (2003). Population Genetic Structure of Anopheles arabiensis Mosquitoes in Ethiopia and Eritrea. Journal of Heredity, 94(6), 457-463. https://doi.org/10.1093/jhered/esg100

Population Genetic Structure of Anopheles arabiensis Mosquitoes in Ethiopia and Eritrea. / Nyanjom, S. R G; Chen, H.; Gebre-Michael, T.; Bekele, E.; Shililu, J.; Githure, J.; Beier, John C; Yan, Guiyun.

In: Journal of Heredity, Vol. 94, No. 6, 01.11.2003, p. 457-463.

Research output: Contribution to journalArticle

Nyanjom, SRG, Chen, H, Gebre-Michael, T, Bekele, E, Shililu, J, Githure, J, Beier, JC & Yan, G 2003, 'Population Genetic Structure of Anopheles arabiensis Mosquitoes in Ethiopia and Eritrea', Journal of Heredity, vol. 94, no. 6, pp. 457-463. https://doi.org/10.1093/jhered/esg100
Nyanjom SRG, Chen H, Gebre-Michael T, Bekele E, Shililu J, Githure J et al. Population Genetic Structure of Anopheles arabiensis Mosquitoes in Ethiopia and Eritrea. Journal of Heredity. 2003 Nov 1;94(6):457-463. https://doi.org/10.1093/jhered/esg100
Nyanjom, S. R G ; Chen, H. ; Gebre-Michael, T. ; Bekele, E. ; Shililu, J. ; Githure, J. ; Beier, John C ; Yan, Guiyun. / Population Genetic Structure of Anopheles arabiensis Mosquitoes in Ethiopia and Eritrea. In: Journal of Heredity. 2003 ; Vol. 94, No. 6. pp. 457-463.
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