Polysubstance Use, Mood Disorders, and Chronic Conditions With Anxiety in Opioid Patients

Sophia Liu, Christian Nwabueze, Yue Pan, Suzy Mascaro Walter, Brenda Su, Chun Xu, Erin L. Winstanley, Kesheng Wang

Research output: Contribution to journalArticlepeer-review

Abstract

This study examined the associations of polysubstance use, mood disorders, and chronic conditions with the history of anxiety disorder among patients with opioid use disorder (OUD). We performed a secondary analysis of the baseline data from a clinical trial including 1,645 individuals with OUD, of which 513 had anxiety disorder. Substance use disorders (SUDs) included alcohol, amphetamines, cannabis, cocaine, and sedative use disorders. Mood disorders included major depressive disorder (MDD) and bipolar disorder (BD). Chronic conditions were allergies, gastrointestinal problem(s), skin problem(s), and hypertension. Sedative use disorder, MDD, BD, skin problems, and hypertension were significantly associated with anxiety disorder (p < 0.05). Additionally, more than two SUDs, two mood disorders, and more than two chronic conditions were significantly associated with anxiety disorder (p < 0.05). These findings highlight the comorbid mental health and physical health problems in individuals with OUD, as well as the need for integrated multidisciplinary treatment plans.

Original languageEnglish (US)
JournalWestern Journal of Nursing Research
DOIs
StateAccepted/In press - 2021

Keywords

  • Anxiety disorders
  • Mood disorders
  • Multiple chronic conditions
  • Opioid use disorder
  • Polysubstance use

ASJC Scopus subject areas

  • Nursing(all)

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