Our understanding of aging is constantly evolving, but there is great interest in using polyphenol organic compounds to modify or retard the aging process. Several polyphenols augment the lifespan of multiple invertebrate and vertebrate species, in higher organisms in the presence of dietary modification. Polyphenols may influence aging by acting on genes in energy-regulatory intracellular pathways that are believed to play important roles in the aging process. In addition, or together with this process, polyphenols may alter concentrations of reactive oxygen species, the Klotho gene, transcription factors, and act via epigenetic mechanisms. Polyphenols may also modulate organ systems through their effect on intercellular signaling molecules including nitrous oxide and pro-inflammatory cytokines. Many unanswered questions remain, including the optimal forms to use, endpoints to study, and how to tackle the problem of limited bioavailability. Newer forms of computer-based genetic and molecular analyses may assist in the selection of appropriate targets for study.
|Original language||English (US)|
|Title of host publication||Molecular Basis of Nutrition and Aging|
|Subtitle of host publication||A Volume in the Molecular Nutrition Series|
|Number of pages||9|
|State||Published - Apr 28 2016|
- Reactive oxygen species
ASJC Scopus subject areas