Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer

Tasha R. Smith, Mark Steven Miller, Kurt Lohman, Ethan M. Lange, L. Douglas Case, Harvey W. Mohrenweiser, Jennifer J. Hu

Research output: Contribution to journalArticle

156 Scopus citations

Abstract

Mammalian cells are constantly exposed to a wide variety of genotoxic agents from both endogenous and exogenous sources. Genetic variability in DNA repair may contribute to human cancer risk. We used a case-control study design (162 cases and 302 controls) to test the association between three amino acid substitution variants of DNA repair genes (XRCC1 Arg194Trp, XRCC1 Arg399Gln, and XRCC3 Thr241Met) and breast cancer susceptibility. We found a weak association between the XRCC1 194Trp allele and breast cancer risk (adjusted odds ratio (OR)=1.98; 95% confidence interval (CI)=0.85-4.63). We also found a potential gene-gene interaction between the XRCC1 194Trp allele and XRCC3 241Met allele and breast cancer risk (adjusted OR=8.74; 95% CI=1.13-67.53). Although larger studies are needed to validate the study results, our data suggest that amino acid substitution variants of XRCC1 and XRCC3 genes may contribute to breast cancer susceptibility.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalCancer letters
Volume190
Issue number2
DOIs
StatePublished - Feb 20 2003
Externally publishedYes

Keywords

  • Breast Cancer
  • DNA repair polymorphisms
  • Genetic susceptibility

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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    Smith, T. R., Miller, M. S., Lohman, K., Lange, E. M., Case, L. D., Mohrenweiser, H. W., & Hu, J. J. (2003). Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer. Cancer letters, 190(2), 183-190. https://doi.org/10.1016/S0304-3835(02)00595-5