Polymorphisms in the transcribed 3′ untranslated region of eukaryotic genes

Research output: Contribution to journalShort surveypeer-review

33 Scopus citations


In this review we present preliminary evidence for a new class of polymorphism that may be used in a systematic way to map cDNAs efficiently and to expedite the construction of a high-resolution genetic map of the human genome. Ultimately, transcribed 3′ untranslated polymorphisms will warrant further study because they should be widely distributed throughout the genome within transcribed sequences, and they can be readily identified as a result of cDNA cloning and sequencing. Furthermore, these markers should be universally available on the basis of the sequence data and highly useful in linkage analyses.

Original languageEnglish (US)
Pages (from-to)484-489
Number of pages6
Issue number2
StatePublished - Oct 1991
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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