Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques

Andrea Weiler, Gemma E. May, Ying Qi, Nancy Wilson, David I. Watkins

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Polymorphisms in several host genes in HIV-infected individuals facilitate slow progression to AIDS. We have identified several SIV-infected Indian rhesus macaques that naturally control viral replication. We investigated whether spontaneous control of SIV in any of these animals could be explained by mutations in host genes. Such variables could confound studies of associations between MHC class I alleles and control of viral replication. We searched for polymorphisms in CCR5, CXCR6, GPR15, RANTES, IL-10, APOBEC3G, TNF-α, and TSG101 and looked for associations with decreased viral replication. We did not detect any correlations between plasma viral concentration and polymorphisms in host genes examined in this study. In addition, we did not find the polymorphisms present in humans in any of our macaques.

Original languageEnglish (US)
Pages (from-to)1003-1009
Number of pages7
JournalImmunogenetics
Volume58
Issue number12
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

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Keywords

  • AIDS progression
  • Genetic polymorphism
  • Rhesus macaque

ASJC Scopus subject areas

  • Immunology
  • Genetics

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