Polymorphism of the HLA-DRB1 locus in Colombian, Ecuadorian and Chilean Amerinds

Nadezda Blagitko, Colm O'Huigin, Felipe Figueroa, Satoshi Horai, Sunro Sonoda, Kazuo Tajima, David Watkins, Jan Klein

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Abstract

We have characterized the DRB1 genotypes in a sample of 64 South American Indians drawn from populations in Chile, Colombia, and Ecuador. No novel DRB1 alleles were found in the total of 17 different alleles characterized, indicating that rapid allelic generation does not occur at the DRB1 loci, in contrast to HLA-B. Comparison between Chilean and Colombian/Ecuadorian samples revealed no major differences in their allelic frequencies. In the combined Amerind sample the HLA-DRB1*0407 and HLA- DRB1*1402 alleles occurred in the highest frequencies (38% and 22%, respectively). Genetic distance measurement showed the HLA-DRB1 frequencies reported here to agree with findings in other Amerind groups. The high frequencies of both HLA-DRB1*0407 and HLA-DRB1*1602 alleles, in conjunction with their absence in Siberian samples, suggest that migratory groups other than Siberians may have been involved in the peopling of the Americas.

Original languageEnglish (US)
Pages (from-to)74-81
Number of pages8
JournalHuman Immunology
Volume54
Issue number1
DOIs
StatePublished - Apr 15 1997

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Blagitko, N., O'Huigin, C., Figueroa, F., Horai, S., Sonoda, S., Tajima, K., Watkins, D., & Klein, J. (1997). Polymorphism of the HLA-DRB1 locus in Colombian, Ecuadorian and Chilean Amerinds. Human Immunology, 54(1), 74-81. https://doi.org/10.1016/S0198-8859(97)00005-0